Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Aires-de-Sousa, Marta ; Ortiz de la Rosa, José Manuel ; Gonçalves, Maria Luísa ; Pereira, Ana Luísa ; Nordmann, Patrice ; Poirel, Laurent
• Description:
  We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013-2018 in a 123-bed hospital in Lisbon. We identified bla| (n = 36), bla| (n = 9), and bla| (n = 8) carbapenemase genes and observed co-occurrence of bla| and bla| in 7 isolates. A single GES-5-producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co-located on the same ColE1-like plasmid. The bla| gene was always located on an IncX3 plasmid, whereas bla| was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L).
• Subjects:
  Antimicrobial Resistance Bacterial Infections BEL-1 Carbapenemase GES-5 Klebsiella Pneumoniae KPC-3 Nosocomial Infections OXA-181 Synopsis
• Source:
  Emerg Infect Dis. 25(9):1632-1638
• Pubmed ID:
  31441424
• Pubmed Central ID:
  PMC6711212
• Document Type:
  Journal Article
• Place as Subject:
  Portugal
• Location:
  Europe
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:24f24285a12901c73dee0486ba4d4692b69302d330bcb72e507d988ea0c857be
• Download URL:
  https://stacks.cdc.gov/view/cdc/81180/cdc_81180_DS1.pdf
• File Type:
  [PDF - 913.38 KB ]