Metallic air pollutants and breast cancer heterogeneity

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Kresovich, Jacob K. ; Erdal, Serap ; Chen, Hua Yun ; Gann, Peter H. ; Argos, Maria ; Rauscher, Garth H.
• Description:
  Background:
  
  Emerging evidence suggests airborne metals may be associated with breast cancer risk. However, breast cancer is heterogenous and associations with heavy metals vary by subtype. Heavy metals possess both carcinogenic and xenoestrogenic properties which may be related to different tumor etiologies. Therefore, we tested for etiologic heterogeneity, using a case-series approach, to determine whether associations between residential airborne metal concentrations and breast cancer differed by tumor subtype.
  
  Methods:
  
  Between 2005–2008, we enrolled incident breast cancer cases into the Breast Cancer Care in Chicago study. Tumor estrogen and progesterone receptors status was determined by medical record abstraction and confirmed immunohistochemically (N=696; 147 ER/PR-negative). The 2002 USEPA’s National Air Toxics Assessment census-tract estimates of metal concentrations (antimony, arsenic, beryllium, cadmium, chromium, cobalt, lead, manganese, mercury, nickel and selenium) were matched to participants’ residences of the same year. Adjusted logistic regression models were used to examine whether the airborne heavy metal associations differed by tumor ER/PR status. Principal component analysis was performed to assess associations by metal co-exposures.
  
  Results:
  
  Comparing the highest and lowest quintiles, higher concentrations of antimony (odds ratio[OR]: 1.8, 95% confidence interval[CI]: 0.9, 3.7, P-trend: 0.05), cadmium (OR: 2.3, 95% CI: 1.2, 4.4, P-trend: 0.04) and cobalt (OR: 2.0, 95% CI: 0.9, 4.4, P-trend: 0.04) were associated with ER/PR-negative breast cancer. Mixture analysis using principal components suggested co-exposures to multiple airborne heavy metals may drive associations with tumor receptor status.
  
  Conclusions:
  
  Among women diagnosed with breast cancer, metallic air pollutants were associated with increased odds of developing ER/PR-negative breast cancer.
  
  
• Keywords:
  Air Pollutants Air Pollution Breast Breast Cancer Breast Neoplasms Cadmium Environmental Exposure ER/PR Status Female Heavy Metals Humans Metals, Heavy NATA Risk Factors

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• Source:
  Environ Res. 177:108639
• Pubmed ID:
  31419716
• Pubmed Central ID:
  PMC6717519
• Document Type:
  Journal Article
• Funding:
  P50 CA106743/CA/NCI NIH HHSUnited States/ ; R25 CA057699/CA/NCI NIH HHSUnited States/ ; T42 OH008672/OH/NIOSH CDC HHSUnited States/
• Volume:
  177
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:20d5d8b845dff5b422f39c93cba59f33e090dda65782e802da60ee6ab4f175b4
• Download URL:
  https://stacks.cdc.gov/view/cdc/81080/cdc_81080_DS1.pdf
• File Type:
  [PDF - 576.47 KB ]