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Risk factors for multidrug-resistant organisms among deceased organ donors
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9 2019
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Source: Am J Transplant. 19(9):2468-2478
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Alternative Title:Am J Transplant
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Description:Donor infection or colonization with a multidrug-resistant organism (MDRO) affects organ utilization and recipient antibiotic management. Approaches to identifying donors at risk of carrying MDROs are unknown. We sought to determine the risk factors for MDROs among transplant donors. A multicenter retrospective cohort study was conducted at four transplant centers between 2015 and 2016. All deceased donors who donated at least one organ were included. Cultures obtained during the donor's terminal hospitalization and organ procurement were evaluated. The primary outcome was isolation of an MDRO on culture. Multivariable Cox regression was used to determine risk factors associated with time to donor MDRO. Of 440 total donors, 64 (15%) donors grew an MDRO on culture. Predictors of an MDRO on donor culture included hepatitis C viremia (hazard ratio [HR] 4.09, 95% confidence interval [CI] 1.71-9.78, P = .002), need for dialysis (HR 4.59, 95% CI 1.09-19.21, P = .037), prior hematopoietic cell transplant (HR 7.57, 95% CI 1.03-55.75, P = .047), and exposure to antibiotics with a narrow gram-negative spectrum (HR 1.13, 95% CI 1.00-1.27, P = .045). This is the first study to determine risk factors for MDROs among deceased donors and will be important for risk stratifying potential donors and informing transplant recipient prophylaxis.
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Pubmed ID:31162785
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Pubmed Central ID:PMC6711782
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Funding:K24 AI080942/AI/NIAID NIH HHSUnited States/ ; L30 AI133754/AI/NIAID NIH HHSUnited States/ ; Transplant Foundation's Innovative Research Grant ProgramInternational/ ; UM1 AI104681/AI/NIAID NIH HHSUnited States/ ; FOA#CK16-004/Centers for Disease Control and Prevention (CDC), Epicenters for the Prevention of Healthcare Associated InfectionsInternational/ ; ... More +
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Volume:19
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Issue:9
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