Toxoplasmosis in Transplant Recipients, Europe, 2010–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Robert-Gangneux, Florence ; Meroni, Valeria ; Dupont, Damien ; Botterel, Françoise ; Garcia, José M. Aguado ; Brenier-Pinchart, Marie-Pierre ; Accoceberry, Isabelle ; Akan, Hamdi ; Abbate, Isabella ; Boggian, Katia ; Bruschi, Fabrizio ; Carratalà, Jordi ; David, Miruna ; Drgona, Lubos ; Djurković-Djaković, Olgica ; Farinas, Maria Carmen ; Genco, Francesca ; Gkrania-Klotsas, Effrossyni ; Groll, Andreas H. ; Guy, Edward ; Hirzel, Cédric ; Khanna, Nina ; Kurt, Özgür ; Junie, Lia Monica ; Lazzarotto, Tiziana ; Len, Oscar ; Mueller, Nicolas J. ; Munoz, Patricia ; Pana, Zoi Dorothea ; Roilides, Emmanuel ; Stajner, Tijana ; van Delden, Christian ; Villena, Isabelle ; Pelloux, Hervé ; Manuel, Oriol
• Description:
  Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.
• Subjects:
  Adult Hematopoietic Stem Cell Transplantation Humans Middle Aged Organ Transplantation Research Retrospective Studies Risk Factors Toxoplasmosis Transplant Recipients
• Source:
  Emerg Infect Dis. 24(8):1497-1504
• Pubmed ID:
  30014843
• Pubmed Central ID:
  PMC6056100
• Document Type:
  Journal Article
• Place as Subject:
  Europe
• Location:
  Europe
• Volume:
  24
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a335c4cb0de510aba0e211c560e937a1b570b7bbf04f760dc852ea5accaa0444
• Download URL:
  https://stacks.cdc.gov/view/cdc/57961/cdc_57961_DS1.pdf
• File Type:
  [PDF - 527.29 KB ]