Details:

Alternative Title:
Obesity (Silver Spring)
Personal Author:
Dadres, Ghazaleh Sadr ; Whitaker, Kara ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; ... More +
Dadres, Ghazaleh Sadr ; Whitaker, Kara ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; Teague, April M. ; Jacobs, David R. ; Kharbanda, Elyse O. ; McGovern, Patricia M. ; Schoenfuss, Tonya C. ; Le, Laura J. ; Harnack, Lisa ; Fields, David A. ; Demerath, Ellen W. ; Less -
Description:
Objective: To test associations of pre-pregnancy BMI (BMI), gestational weight gain (GWG), oral glucose challenge test (OGCT) results, and post-partum weight loss (PPWL) as predictors of breastmilk leptin, insulin and adiponectin concentrations, and whether these relationships vary over time. Methods: Milk was collected at 1- and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed effects linear regression models were employed to assess main effects and effect-by-time interactions on hormone concentrations. Results: In adjusted models, BMI was positively associated with milk leptin (p<0.001) and insulin (p=0.03), and negatively associated with milk adiponectin (p=0.02); however, the association with insulin was stronger and with adiponectin was weaker at 3-months than at 1-month (time interaction p= 0.017 for insulin and p= 0.045 for adiponectin). GWG was positively and PPWL was negatively associated with milk leptin (both p<0.001) independent of BMI. OGCT was not associated with these milk hormone concentrations. Conclusion: Maternal weight status before, during, and after pregnancy contributes to inter-individual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.
Subject:
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Adiponectin
Adult
Article
Body Weight
Breast Feeding
Female
Gestational Weight Gain
Glucose Tolerance Test
Hormones
Humans
Infant, Newborn
Insulin
Leptin
Longitudinal Studies
Male
Maternal Obesity
Middle Aged
Milk, Human
Mothers
Postpartum Period
Pregnancy
Young Adult
Breast Feeding

Source:
Obesity (Silver Spring). 27(4):621-628 ;
Pubmed ID:
30900412
Pubmed Central ID:
PMC6432940
Document Type:
Journal Article ;
Funding:
R01 HD080444/HD/NICHD NIH HHS/United States ; R18 OH003605/OH/NIOSH CDC HHS/United States ;
R01 HD080444/HD/NICHD NIH HHS/United States ; R18 OH003605/OH/NIOSH CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c92548626330d424c4b464999081a119079c79b4de477fa64c804a002900ef52
File Type:

Supporting Files

• 	nihms-1006224.nxml	xml
  	NIHMS1006224-supplement-Supp_figS1.pdf	pdf
  	NIHMS1006224-supplement-Supp_info.docx	docx

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