Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Weaned pigs experimentally infected with Salmonella display sexually dimorphic innate immune responses without affecting pathogen colonization patterns1,2

Filetype[PDF-1021.61 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Transl Anim Sci
    • Personal Author:
    • Description:
      Sexually dimorphic innate immune responses have been observed in several species, but have not been studied in response to a live pathogen challenge in pigs. This study aimed to elucidate sexually dimorphic innate immune responses along with | translocation patterns in newly weaned pigs orally inoculated with |. Newly weaned pigs (| = 8 gilts and 12 barrows; 6.2 ± 0.2 kg BW) were obtained from a commercial swine facility and were maintained in an environmentally-controlled facility in individual pens equipped with feeders and nipple waterers. Pigs were allowed ad libitum access to a commercial non-medicated starter ration and water throughout the study. On d 12 post-weaning, pigs were anesthetized to allow placement of a temperature measuring device in the abdominal cavity for measurement of intraperitoneal temperature (TEMP). On d 17, pigs were anesthetized and fitted with indwelling jugular vein catheters. On the following day (d 18), pigs were orally inoculated with 4.7×10|. Blood samples were collected at 0.5-h intervals from -2 to 8 h, and at 8-h intervals from 8 to 72 h post-challenge. Whole blood was analyzed for complete blood cell counts. Serum was isolated for measurement of cortisol. Following collection of the 72 h sample, pigs were humanely euthanized and tissues were collected for | isolation. There was a sex × time interaction (| < 0.001) for TEMP such that gilts had a greater TEMP response to the | challenge compared to barrows. There was also a sex × time interaction (| = 0.03) for serum cortisol with gilts having decreased cortisol at 16 h yet greater cortisol at 32 h than barrows. Barrows had greater total white blood cells (17.8 vs. 16.2 ± 0.4 10| cells/μL; | < 0.01; respectively) and neutrophils (7.8 vs. 6.1 ± 0.4 10| cells/μL; | < 0.01; respectively) than gilts. However, gilts had greater lymphocytes (9.6 vs. 9.0 ± 0.2 10| cells/μL; | = 0.05; respectively) than barrows. While immune parameters were influenced by sex, there was no effect of sex (| > 0.05) on | concentrations from fecal shedding 3 d post-inoculation in the cecum, mesenteric and subiliac lymph nodes, liver, spleen, gallbladder, or kidney tissues. These data demonstrate that weaned gilts appear to produce a stronger acute phase response to a | challenge compared to barrows, without affecting the tissue translocation or shedding of |.
    • Subjects:
    • Source:
      Transl Anim Sci. 1(1):69-76
    • Pubmed ID:
      31372597
    • Pubmed Central ID:
      PMC6675027
    • Document Type:
      Journal Article
    • Funding:
      T32 OD011083/ODCDC CDC HHS/Office of the Director/United States
    • Collection(s):
    • Main Document Checksum:
    • Download URL:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov