Actigraphy-Based Sleep Parameters During the Reinstatement of Methamphetamine Self-Administration in Rhesus Monkeys

Details

• Alternative Title:
  Exp Clin Psychopharmacol
• Personal Author:
  Berro, Laís F. ; Andersen, Monica L. ; Tufik, Sergio ; Howell, Leonard L.
• Description:
  The objective of this study was to investigate nighttime activity of nonhuman primates during extinction and cue- and drug-primed reinstatement of methamphetamine self-administration. Adult rhesus monkeys (Macaca mulatta; n = 5) self-administered methamphetamine (0.01 mg/kg/injection, i.v.) under a fixed-ratio 20 schedule of reinforcement. Saline infusions were then substituted for methamphetamine and stimulus light (drug-conditioned stimulus presented during drug self-administration) withheld until subjects reached extinction criteria. Drug- and cue-induced reinstatement effects were evaluated after i.v. noncontingent priming injections of methamphetamine (0.03, 0.1, or 0.3 mg/kg). Activity-based sleep measures were evaluated with Actiwatch monitors a week before (baseline nighttime activity parameters) and throughout the protocol. Although methamphetamine self-administration did not significantly affect nighttime activity compared to baseline, sleeplike parameters were improved during extinction compared to self-administration maintenance. Priming injection of 0.1 mg/kg methamphetamine, but not 0.03 or 0.3 mg/kg, induced significant reinstatement effects. These behavioral responses were accompanied by nighttime outcomes, with increased sleep fragmentation and decreased sleep efficiency in the night following 0.1 mg/kg methamphetamine-induced reinstatement. In the absence of both drug and drug-paired cues (extinction conditions), nighttime activity decreased compared to self-administration maintenance. Additionally, effective reinstatement conditions impaired sleeplike measures. Our data indicate that the reintroduction of the stimulus light as a drug-paired cue increased nighttime activity.
• Subjects:
  Actigraphy Animals Article Conditioning, Operant Cues Dose-Response Relationship, Drug Extinction, Psychological Female Macaca Mulatta Male Methamphetamine Nighttime Activity Reinforcement Schedule Reinstatement Rhesus Monkeys Self-administration Self Administration Sleep Time Factors

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• Source:
  Exp Clin Psychopharmacol. 24(2):142-146
• Pubmed ID:
  26882419
• Pubmed Central ID:
  PMC4795967
• Document Type:
  Journal Article
• Funding:
  DA10344/DA/NIDA NIH HHS/United States ; DA031246/DA/NIDA NIH HHS/United States ; P51 OD011132/ODCDC CDC HHS/Office of the Director/United States ; ODP51OD11132/PHS HHS/United States ; R01 DA010344/NIDA NIH HHS/National Institute on Drug Abuse/United States ; K05 DA031246/NIDA NIH HHS/National Institute on Drug Abuse/United States
• Volume:
  24
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7b3ecd6f1a3f7d79f86f39f0bbebea85b04448d2c0240c0c35dd47fead660b8e
• Download URL:
  https://stacks.cdc.gov/view/cdc/80473/cdc_80473_DS1.pdf
• File Type:
  [PDF - 361.89 KB ]