Pseudomonas poae–Associated Fatal Septic Transfusion Reaction, Peoria, Illinois, USA, 2017

Woodring, Therese S.; Farrell, John J.

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Pseudomonas poae–Associated Fatal Septic Transfusion Reaction, Peoria, Illinois, USA, 2017

Supporting Files Public Domain

August 2019
By Woodring, Therese S. ; Farrell, John J.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Woodring, Therese S. ; Farrell, John J.
Description:

In the United States, fatal transfusion-transmitted infections from red blood cell units are rare. Although this pattern mostly reflects how inhospitable refrigerated red blood cell units are to contaminant growth, fatalities caused by microorganisms that can grow at storage temperature (4°C), but not in standard clinical blood cultures at 37°C, are probably underestimated. We analyzed a fatal red blood cell transfusion in Peoria, Illinois, USA, that occurred in 2017. Samples from the patient's whole blood and the red blood cell unit remained culture-negative during the investigation, despite direct visualization of gram-negative bacilli within the unit immediately after transfusion. We identified the bacteria as Pseudomonas poae, a nonpathogenic pseudomonad carrying multiple cold-shock domain protein genes, and confirmed its cold tolerance and inability to grow at 37°C. Our work indicates transfusion reaction workups need to include testing for psychrophilic organisms, which could explain the cause of other apparently culture-negative transfusion reactions.
Subjects:

Bacteria Cold-Tolerant Bacteria Fatality Gram-Negative Bacteria Pseudomonas Pseudomonas Poae Psychrophilic Bacterium Red Blood Cell Transfusion Sepsis Septic Transfusion Reaction Synopsis Transfusion-Transmitted Infection Transfusion Reaction Whole-Genome Sequencing
Source:

Emerg Infect Dis. 25(8):1445-1451
Pubmed ID:

31310217
Pubmed Central ID:

PMC6649322
Document Type:

Journal Article
Place as Subject:

Illinois
Location:

North America
Volume:

25
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2c45153a922905344d49f93d7679c58766c49770ff7877b0cde97739f0bcf6ee
Download URL:

https://stacks.cdc.gov/view/cdc/80328/cdc_80328_DS1.pdf
File Type:

[PDF - 963.87 KB ]

File Language:

English

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