Details:

Alternative Title:
Influenza Other Respir Viruses
Personal Author:
Hughes, Michelle M. ; Praphasiri, Prabda ; Dawood, Fatimah S. ; Sornwong, Kanlaya ; Ditsungnoen, Darunee ; ... More +
Hughes, Michelle M. ; Praphasiri, Prabda ; Dawood, Fatimah S. ; Sornwong, Kanlaya ; Ditsungnoen, Darunee ; Mott, Joshua A. ; Prasert, Kriengkrai Less -
Description:
Background

Frailty is associated with increased risk of mortality and decline in functional status among older adults. Older adults are at increased risk of severe disease from acute respiratory illness (ARIs), but ARI effects on frailty status among older adults are not well understood. We evaluated how ARIs affect short‐term frailty status among community‐dwelling adults aged ≥65 years in Nakhon Phanom, Thailand.

Methods

During May 2015 to May 2017, older adults were contacted weekly to identify ARIs as part of a community‐based longitudinal cohort study. Each participant's frailty status was assessed at baseline and every 6 months using the Vulnerable Elders Survey‐13 (VES‐13). We selected cohort participants with an ARI and compared them with a sample of participants without an ARI matched on age, sex, influenza vaccination status, and most recent VES‐13 score. For these matched cohort members, an additional VES‐13 was recorded at 3‐4 weeks after the ARI episode date.

Results

Of 3220 cohort study participants, 114 participants with an ARI and 111 comparison participants without an ARI were selected for the matched cohort; three comparison participants were matched to two ARI cases. We found no statistically significant difference between ARI and non‐ARI participants in modified VES‐13 score 3‐4 weeks post‐episode (cases = 0.90, controls = 0.63, P = 0.07). Only two ARI episodes required hospitalization.

Conclusions

Primarily mild ARIs did not affect short‐term frailty status among community‐dwelling older adults in Thailand. As few cases of severe ARI were detected, the contribution of severe ARI to changes in frailty requires further investigation.


Subjects:
[+]
Aged Aged, 80 And Over Age Factors Female Frail Elderly Frailty Humans Longitudinal Studies Male Prospective Studies Respiratory Tract Infections
Source:
Influenza Other Respir Viruses. 13(4):391-397
Pubmed ID:
30848082
Pubmed Central ID:
PMC6586187
Document Type:
Journal Article
Funding:
U01 GH002084/GH/CGH CDC HHS/United States
Place as Subject:
Thailand
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5e7faa6888c839c3e39b8f3b4c70c600c395d08fb438820aa70d0ffaa53bc57d
Download URL:
https://stacks.cdc.gov/view/cdc/79716/cdc_79716_DS1.pdf
File Type:

Supporting Files

• 	IRV-13-391-g001.gif	gif
  	IRV-13-391-g001.jpg	jpeg
  	IRV-13-391-s001.docx	docx
  	IRV-13-391-s002.docx	docx
  	IRV-13-391-s003.docx	docx
  	IRV-13-391.nxml	xml

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