Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008–2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Thorlacius-Ussing, Louise ; Sandholdt, Haakon ; Larsen, Anders Rhod ; Petersen, Andreas ; Benfield, Thomas
• Description:
  Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008-2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observed for persons >80 years of age: a 90% increase in the SAB rate (p<0.001). After adjusting for demographic changes, annual rates increased 4.0% (95% CI 3.0-5.0) for persons <80 years of age, 8.4% (95% CI 7.0-11.0) for persons 80-89 years of age, and 13.0% (95% CI 9.0-17.5) for persons >90 years of age. The 30-day case-fatality rate remained stable at 24%; crude population death rates increased by 53% during 2008-2015 (p<0.001). Specific causes and mechanisms for this rapid increase in SAB incidence among the elderly population remain to be clarified.
• Subjects:
  Age-Dependent Increase In Incidence Of Staphylococcus Aureus Bacteremia, Denmark, 2008–2015 Aging Bacteremia Bacteria Elderly Epidemiology Incidence Population Research Staphylococci Staphylococcus Aureus

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• Source:
  Emerg Infect Dis. 25(5):875-882
• Pubmed ID:
  31002300
• Pubmed Central ID:
  PMC6478196
• Document Type:
  Journal Article
• Place as Subject:
  Denmark
• Location:
  Europe
• Volume:
  25
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:74ee31f86b092cf3cb297db35a9c007aa05ad9e4f7d2939228b25f7fc04da955
• Download URL:
  https://stacks.cdc.gov/view/cdc/79358/cdc_79358_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]