Isolation of Lagos Bat Virus from Water Mongoose
Published Date:Dec 2006
Source:Emerg Infect Dis. 12(12):1913-1918.
Fluorescent Antibody Technique, Indirect
Lagos Bat Virus
Mice, Inbred ICR
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Description:A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa. The virus isolate was confirmed as LBV by antigenic and genetic characterization, and the mongoose was identified as Atilax paludinosus by mitochondrial cytochrome b sequence analysis. Phylogenetic analysis demonstrated sequence homology with previous LBV isolates from South African bats. Studies performed in mice indicated that the peripheral pathogenicity of LBV had been underestimated in previous studies. Surveillance strategies for LBV in Africa must be improved to better understand the epidemiology of this virus and to make informed decisions on future vaccine strategies because evidence is insufficent that current rabies vaccines provide protection against LBV.
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