West Nile Virus Infections Projected from Blood Donor Screening Data, United States, 2003

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Busch, Michael P. ; Wright, David J. ; Custer, Brian ; Tobler, Leslie H. ; Stramer, Susan L. ; Kleinman, Steven H. ; Prince, Harry E. ; Bianco, Celso ; Foster, Gregory ; Petersen, Lyle R. ; Nemo, George ; Glynn, Simone A.
• Description:
  National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-NAT were used to estimate incident infections in 2003. WNV donor screening yielded 944 confirmed viremic donors. MP-NAT yield peaked in August with >0.5% of donations positive for WNV RNA in 4 states. Peak IgM seroprevalence for North Dakota was 5.2% in late September. The average time viremia is detectable by MP-NAT was 6.9 days (95% confidence interval [CI] 3.0-10.7). An estimated 735,000 (95% CI 322,000-1,147,000) infections occurred in 2003, with 256 (95% CI 112-401) infections per neuroinvasive case. In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population.
• Subjects:
  Blood Donors Humans Incidence Mass Screening Research RNA, Viral Seasons Sensitivity And Specificity Time Factors West Nile Fever
• Source:
  Emerg Infect Dis. 12(3):395-402.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  12
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3995091a631ffcc985622014982f3bdd4333edcaaf43d6c5ff480bb4402c9ea4
• Download URL:
  https://stacks.cdc.gov/view/cdc/7907/cdc_7907_DS1.pdf
• File Type:
  [PDF - 199.65 KB ]