i
West Nile Virus Infections Projected from Blood Donor Screening Data, United States, 2003
-
Mar 2006
-
-
Source: Emerg Infect Dis. 12(3):395-402.
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-NAT were used to estimate incident infections in 2003. WNV donor screening yielded 944 confirmed viremic donors. MP-NAT yield peaked in August with >0.5% of donations positive for WNV RNA in 4 states. Peak IgM seroprevalence for North Dakota was 5.2% in late September. The average time viremia is detectable by MP-NAT was 6.9 days (95% confidence interval [CI] 3.0-10.7). An estimated 735,000 (95% CI 322,000-1,147,000) infections occurred in 2003, with 256 (95% CI 112-401) infections per neuroinvasive case. In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population.
-
Subjects:
-
Source:
-
Document Type:
-
Place as Subject:
-
Location:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: