women

Details

• Alternative Title:
  Epidemiology
• Personal Author:
  Sangaramoorthy, Meera ; Hines, Lisa M. ; Torres-Mejía, Gabriela ; Phipps, Amanda I. ; Baumgartner, Kathy B. ; Wu, Anna H. ; Koo, Jocelyn ; Ingles, Sue A. ; Slattery, Martha L. ; John, Esther M.
• Description:
  Background:
  
  Data on breast-feeding and breast cancer risk are sparse and inconsistent for Hispanic women.
  
  Methods:
  
  Pooling data for nearly 6,000 parous Hispanic women from four population-based studies conducted between 1995 and 2007 in the U.S. and Mexico, we examined the association of breast-feeding with risk of breast cancer overall and subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status, as well as the joint effects of breast-feeding, parity, and age at first birth. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression.
  
  Results:
  
  Among parous Hispanic women, older age at first birth was associated with increased breast cancer risk, whereas parity was associated with reduced risk. These associations were found for hormone receptor positive (HR+) breast cancer only and limited to premenopausal women. Age at first birth and parity were not associated with risk of ER-PR-breast cancer. Increasing duration of breast-feeding was associated with decreasing breast cancer risk (≥25 vs. 0 months: OR=0.73, 95% CI=0.60–0.89, Ptrend =0.03), with no heterogeneity by menopausal status or subtype. At each parity level, breast-feeding further reduced HR+ breast cancer risk. Additionally, breast-feeding attenuated the increase in risk of HR+ breast cancer associated with older age at first birth.
  
  Conclusions:
  
  Our findings suggest that breast-feeding is associated with reduced risk of both HR+ and ER-PR-breast cancer among Hispanic women, as reported for other populations, and may attenuate the increased risk in women with a first pregnancy at older ages.
  
  
• Subjects:
  Adult Aged Breast Feeding Breast Neoplasms Female Hispanic Or Latino Humans Middle Aged Parity Pregnancy Receptors, Estrogen Receptors, Progesterone Risk Factors

  More +
• Source:
  Epidemiology. 30(3):449-457
• Pubmed ID:
  30964816
• Pubmed Central ID:
  PMC6472273
• Document Type:
  Journal Article
• Funding:
  UM1 CA164920/CA/NCI NIH HHS/United States ; R03 CA199343/CA/NCI NIH HHS/United States ; R01 CA078552/CA/NCI NIH HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; R01 CA078762/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; R01 CA078802/CA/NCI NIH HHS/United States ; R01 CA078682/CA/NCI NIH HHS/United States ; R01 CA140002/CA/NCI NIH HHS/United States ; R01 CA063446/CA/NCI NIH HHS/United States ; U01 CA164920/CA/NCI NIH HHS/United States
• Place as Subject:
  Mexico ; United States
• Volume:
  30
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:714fa10a842dbea92238d9e7596c19f612630e1fa814fd8d8d6a156c087fe086
• Download URL:
  https://stacks.cdc.gov/view/cdc/77656/cdc_77656_DS1.pdf
• File Type:
  [PDF - 128.77 KB ]