Maternal Residential Exposure to Specific Agricultural Pesticide Active Ingredients and Birth Defects in a 2003-2005 North Carolina Birth Cohort

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Rappazzo, Kristen M. ; Warren, Joshua L. ; Davalos, Angel D ; Meyer, Robert E. ; Sanders, Alison P. ; Brownstein, Naomi C. ; Luben, Thomas J.
• Description:
  Background: ; Previously we observed elevated odds ratios (ORs) for total pesticide exposure and ten birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients. ; Methods: ; Cases were live-born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth records for 2003–2005; non-cases served as controls (total n=304,906). Pesticide active ingredient exposure was assigned using a previously constructed metric based on crops within 500 meters of residence, dates of pregnancy, and likely chemical application dates for each pesticide-crop combination. ORs (95% CI) were estimated with logistic regression for categories of exposure compared to unexposed. Models were adjusted for maternal race/ethnicity, age at delivery, education, marital status, and smoking status. ; Results: ; Associations varied by birth defect and pesticide combinations. For example, hypospadias was positively associated with exposures to 2,4-D (OR50-<90th percentile: 1.39 (1.18, 1.64)), mepiquat (OR50-<90th percentile: 1.10 (0.90, 1.34)), paraquat (OR50-<90th: 1.14 (0.93, 1.39)), and pendimethalin (OR50-<90th: 1.21 (1.01, 1.44)), but not S-metolachlor (OR50-<90th: 1.00 (0.81, 1.22)). Whereas atrial septal defects were positively associated with higher levels of exposure to glyphosate, cyhalothrin, S-metolachlor, mepiquat, and pendimethalin (ORs ranged from 1.22 to 1.35 for 50-<90th exposures, and 1.72 to 2.09 for >90th exposures); associations with paraquat were null or inconsistent (OR 50-<90th: 1.05 (0.87, 1.27). ; Conclusion: ; Our results suggest differing patterns of association for birth defects with residential exposure to seven pesticide active ingredients in North Carolina.
• Subjects:
  • Adult
  • Case-Control Studies
  • Congenital Abnormalities
  • Environmental Exposure
  • Female
  • Humans
  • Infant
  • Male
  • Maternal Exposure
  • Pesticides
  More +
• Source:
  Birth Defects Res. 111(6):312-323
• Pubmed ID:
  30592382
• Pubmed Central ID:
  PMC6445756
• Document Type:
  Journal Article
• Funding:
  P30 ES010126/ES/NIEHS NIH HHS/United States ; R03 HD045780/HD/NICHD NIH HHS/United States ; K99 ES027508/ES/NIEHS NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; T32 ES007018/ES/NIEHS NIH HHS/United States ; R01 ES020619/ES/NIEHS NIH HHS/United States ; U01 DD001231/DD/NCBDD CDC HHS/United States ; KL2 TR001862/TR/NCATS NIH HHS/United States ; EPA999999/Intramural EPA/United States
• Place as Subject:
  North Carolina
• Volume:
  111
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/77181/cdc_77181_DS1.pdf
• File Type:
  [PDF - 1.58 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:620c58a51dcd0c67145679a01f5d4c581f6a8243cb7a259293f8740462aa7b58