Details:

Alternative Title:
Birth Defects Res
Personal Author:
Rappazzo, Kristen M. ; Warren, Joshua L. ; Davalos, Angel D ; Meyer, Robert E. ; Sanders, Alison P. ; ... More +
Rappazzo, Kristen M. ; Warren, Joshua L. ; Davalos, Angel D ; Meyer, Robert E. ; Sanders, Alison P. ; Brownstein, Naomi C. ; Luben, Thomas J. Less -
Description:
Background:

Previously we observed elevated odds ratios (ORs) for total pesticide exposure and ten birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients.

Methods:

Cases were live-born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth records for 2003–2005; non-cases served as controls (total n=304,906). Pesticide active ingredient exposure was assigned using a previously constructed metric based on crops within 500 meters of residence, dates of pregnancy, and likely chemical application dates for each pesticide-crop combination. ORs (95% CI) were estimated with logistic regression for categories of exposure compared to unexposed. Models were adjusted for maternal race/ethnicity, age at delivery, education, marital status, and smoking status.

Results:

Associations varied by birth defect and pesticide combinations. For example, hypospadias was positively associated with exposures to 2,4-D (OR50-<90th percentile: 1.39 (1.18, 1.64)), mepiquat (OR50-<90th percentile: 1.10 (0.90, 1.34)), paraquat (OR50-<90th: 1.14 (0.93, 1.39)), and pendimethalin (OR50-<90th: 1.21 (1.01, 1.44)), but not S-metolachlor (OR50-<90th: 1.00 (0.81, 1.22)). Whereas atrial septal defects were positively associated with higher levels of exposure to glyphosate, cyhalothrin, S-metolachlor, mepiquat, and pendimethalin (ORs ranged from 1.22 to 1.35 for 50-<90th exposures, and 1.72 to 2.09 for >90th exposures); associations with paraquat were null or inconsistent (OR 50-<90th: 1.05 (0.87, 1.27).

Conclusion:

Our results suggest differing patterns of association for birth defects with residential exposure to seven pesticide active ingredients in North Carolina.


Subjects:
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Adult Agricultural Pesticides Article Birth Defects Case-Control Studies Congenital Abnormalities Environmental Exposure Female Humans Infant Male Maternal Exposure North Carolina Pesticides Pregnancy Prenatal Exposure Delayed Effects Time Factors Young Adult
Source:
Birth Defects Res. 111(6):312-323
Pubmed ID:
30592382
Pubmed Central ID:
PMC6445756
Document Type:
Journal Article
Funding:
P30 ES010126/ES/NIEHS NIH HHS/United States ; R03 HD045780/HD/NICHD NIH HHS/United States ; K99 ES027508/ES/NIEHS NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; T32 ES007018/ES/NIEHS NIH HHS/United States ; ... More +
P30 ES010126/ES/NIEHS NIH HHS/United States ; R03 HD045780/HD/NICHD NIH HHS/United States ; K99 ES027508/ES/NIEHS NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; T32 ES007018/ES/NIEHS NIH HHS/United States ; R01 ES020619/ES/NIEHS NIH HHS/United States ; U01 DD001231/DD/NCBDD CDC HHS/United States ; KL2 TR001862/TR/NCATS NIH HHS/United States ; EPA999999/Intramural EPA/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:620c58a51dcd0c67145679a01f5d4c581f6a8243cb7a259293f8740462aa7b58
Download URL:
https://stacks.cdc.gov/view/cdc/77181/cdc_77181_DS1.pdf
File Type:

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