Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Dawson, April L. ; Razzaghi, Hilda ; Arth, Annelise ; Canfield, Mark A. ; Parker, Samantha E. ; ... More +
Dawson, April L. ; Razzaghi, Hilda ; Arth, Annelise ; Canfield, Mark A. ; Parker, Samantha E. ; Reefhuis, Jennita Less -
Description:
Background

Our objective was to describe time trends in selected pregnancy exposures in the National Birth Defects Prevention Study (NBDPS).

Methods

We analyzed data from the NBDPS, a multi-site case-control study of major birth defects, for mothers of live-born infants without birth defects (controls), with an expected date of delivery (EDD) from 1998 –2011. Mothers from the 10 participating centers across the United States were interviewed by phone between six weeks and two years after the EDD. We focused on maternal race/ethnicity and five maternal risk factors: obesity, use of folic acid-containing multivitamins, opioid analgesics, selective serotonin reuptake inhibitors (SSRIs), and loratadine because of their prevalence of use and some reports of associations with major birth defects. Prevalence time trends were examined using the Kendall’s τβ test statistic.

Results

The exposure trend analysis included 11,724 control mothers with EDDs from 1998–2011. We observed a significant increase in obesity prevalence among control mothers, as well as use of SSRIs and loratadine. We also observed an increase in periconceptional use of folic acid-containing multivitamins. Some of the time trends varied by race/ethnicity. No remarkable trend in the overall use of opioid analgesics was observed. The racial/ethnic distribution of mothers changed slightly during the study period.

Conclusions

Long-term, population-based case-control studies continue to be an effective way to assess exposure-birth defects associations and provide guidance to health care providers. However, investigators examining rare outcomes covering many years of data collection need to be cognizant of time trends in exposures.


Subjects:
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Adult Analgesics, Opioid Anti-Allergic Agents Case-Control Studies Congenital Abnormalities Ethnicity Female Folic Acid Humans Loratadine Maternal Exposure Obesity Pregnancy Prenatal Exposure Delayed Effects Serotonin Uptake Inhibitors Time Factors Vitamins
Source:
Birth Defects Res A Clin Mol Teratol. 103(8):703-712.
Pubmed ID:
25884728
Pubmed Central ID:
PMC4617636
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:abcc207c0b67103dcfffb555d89f7082d510575f95162a5299616fc27dc8e403
Download URL:
https://stacks.cdc.gov/view/cdc/35296/cdc_35296_DS1.pdf
File Type:

Supporting Files

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