Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine

Details

• Alternative Title:
  Circ Res
• Personal Author:
  Shamagian, Lillian Grigorian ; Madonna, Rosalinda ; Taylor, Doris ; Climent, Andreu M. ; Prosper, F Felipe ; Bras-Rosario, Luis ; Bayes-Genis, Antoni ; Ferdinandy, Peter ; Fernández-Avilés, F Francisco ; Belmonte, Juan Carlos Izpisua ; Fuster, Valentin ; Bolli, Roberto
• Description:
  The myocardium consists of numerous cell types embedded in organized layers of ECM (extracellular matrix) and requires an intricate network of blood and lymphatic vessels and nerves to provide nutrients and electrical coupling to the cells. Although much of the focus has been on cardiomyocytes, these cells make up <40% of cells within a healthy adult heart. Therefore, repairing or regenerating cardiac tissue by merely reconstituting cardiomyocytes is a simplistic and ineffective approach. In fact, when an injury occurs, cardiac tissue organization is disrupted at the level of the cells, the tissue architecture, and the coordinated interaction among the cells. Thus, reconstitution of a functional tissue must reestablish electrical and mechanical communication between cardiomyocytes and restore their surrounding environment. It is also essential to restore distinctive myocardial features, such as vascular patency and pump function. In this article, we review the current status, challenges, and future priorities in cardiac regenerative or reparative medicine. In the first part, we provide an overview of our current understanding of heart repair and comment on the main contributors and mechanisms involved in innate regeneration. A brief section is dedicated to the novel concept of rejuvenation or regeneration, which we think may impact future development in the field. The last section describes regenerative therapies, where the most advanced and disruptive strategies used for myocardial repair are discussed. Our recommendations for priority areas in studies of cardiac regeneration or repair are summarized in Tables 1 and 2 .
• Keywords:
  Cardiac Rejuvenation Fibroblasts Humans Inflammation Myocardial Regeneration Myocytes, Cardiac Regeneration Regenerative Knowledge Gaps Regenerative Medicine Regenerative Treatments
• Source:
  Circ Res. 124(6):938-951
• Pubmed ID:
  30870121
• Pubmed Central ID:
  PMC6442739
• Document Type:
  Journal Article
• Funding:
  R37 HL055757/HL/NHLBI NIH HHSUnited States/ ; R01 HL076794/HL/NHLBI NIH HHSUnited States/ ; R01 HL055757/HL/NHLBI NIH HHSUnited States/ ; R01 HL070897/HL/NHLBI NIH HHSUnited States/ ; H75 DP424252/DP/NCCDPHP CDC HHSUnited States/ ; P01 HL078825/HL/NHLBI NIH HHSUnited States/ ; UM1 HL113530/HL/NHLBI NIH HHSUnited States/ ; U24 HL094373/HL/NHLBI NIH HHSUnited States/ ; R01 HL068088/HL/NHLBI NIH HHSUnited States/
• Volume:
  124
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6e548fcf24b83a803c4008204bd35bb7de22317520fcbd1b3d102c349adde8b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/77171/cdc_77171_DS1.pdf
• File Type:
  [PDF - 781.33 KB ]