Arrhythmia in Stem Cell Transplantation
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Published Date:Apr 09 2015
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Publisher's site:
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Source:Card Electrophysiol Clin. 2015; 7(2):357-370.
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Pubmed ID:26002399
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Pubmed Central ID:PMC4441953
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Description:Stem cell regenerative therapies hold promise for treating diseases across the spectrum of medicine. While significant progress has been made in the preclinical stages, the clinical application of cardiac cell therapy is limited by technical challenges. Certain methods of cell delivery, such as intramyocardial injection, carry a higher rate of arrhythmias. Other potential contributors to the arrhythmogenicity of cell transplantation include reentrant pathways caused by heterogeneity in conduction velocities between graft and host as well as graft automaticity. In this article, the arrhythmogenic potential of cell delivery to the heart is discussed.
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