Arrhythmia in Stem Cell Transplantation

Almeida, Shone O.; Skelton, Rhys J.; Adigopula, Sasikanth; Ardehali, Reza

doi:10.1016/j.ccep.2015.03.012

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Arrhythmia in Stem Cell Transplantation

Published Date:

Apr 09 2015

Publisher's site:

http://dx.doi.org/10.1016/j.ccep.2015.03.012 New Site Icon

Source:

Card Electrophysiol Clin. 2015; 7(2):357-370.

[PDF - 702.10 KB]

Details:

Personal Authors:

Almeida, Shone O. ; Skelton, Rhys J. ; Adigopula, Sasikanth ; Ardehali, Reza ;

Keywords:

[+]

Pubmed ID:

26002399

Pubmed Central ID:

PMC4441953

Description:

Stem cell regenerative therapies hold promise for treating diseases across the spectrum of medicine. While significant progress has been made in the preclinical stages, the clinical application of cardiac cell therapy is limited by technical challenges. Certain methods of cell delivery, such as intramyocardial injection, carry a higher rate of arrhythmias. Other potential contributors to the arrhythmogenicity of cell transplantation include reentrant pathways caused by heterogeneity in conduction velocities between graft and host as well as graft automaticity. In this article, the arrhythmogenic potential of cell delivery to the heart is discussed.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 HL127728/HL/NHLBI NIH HHS/United States
DP2HL127728/DP/NCCDPHP CDC HHS/United States

Supporting Files:

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