Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Abed, Yacine ; Fage, Clément ; Lagüe, Patrick ; Carbonneau, Julie ; Papenburg, Jesse ; ... More +
Abed, Yacine ; Fage, Clément ; Lagüe, Patrick ; Carbonneau, Julie ; Papenburg, Jesse ; Vinh, Donald C. ; Boivin, Guy Less -
Description:
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374 residue. The potential emergence of such variants emphasizes the need for new antivirals.
Subject:
[+]
Antiviral Agents
Dose-Response Relationship, Drug
Drug Resistance, Viral
Enzyme Inhibitors
Female
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza, Human
Influenza B Virus
Microbial Sensitivity Tests
Middle Aged
Mutation
Neuraminidase
Sequence Analysis, DNA
Viral Proteins

Source:
Emerg Infect Dis. 25(4):838-840
Pubmed ID:
30882323
Pubmed Central ID:
PMC6433030
Document Type:
Letter
Place as Subject:
Canada
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6fe734b7a07a2ffb6097ada7d6dec33177ae6c7e157a7d040bc98bb17745c9f3
File Type:

Supporting Files

• 	18-1554-Techapp-s1.pdf	pdf
  	18-1554.nxml	xml

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