Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Abed, Yacine ; Fage, Clément ; Lagüe, Patrick ; Carbonneau, Julie ; Papenburg, Jesse ; Vinh, Donald C. ; Boivin, Guy
• Description:
  We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374 residue. The potential emergence of such variants emphasizes the need for new antivirals.
• Subjects:
  Antiviral Agents Dose-Response Relationship, Drug Drug Resistance, Viral Enzyme Inhibitors Female Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza B Virus Microbial Sensitivity Tests Middle Aged Mutation Neuraminidase Sequence Analysis, DNA Viral Proteins

  More +
• Source:
  Emerg Infect Dis. 25(4):838-840
• Pubmed ID:
  30882323
• Pubmed Central ID:
  PMC6433030
• Document Type:
  Journal Article
• Genre:
  Letter
• Place as Subject:
  Canada
• Volume:
  25
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6fe734b7a07a2ffb6097ada7d6dec33177ae6c7e157a7d040bc98bb17745c9f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/77157/cdc_77157_DS1.pdf
• File Type:
  [PDF - 295.88 KB ]