Utility of Whole-Genome Sequencing to Ascertain Locally Acquired Cases of Coccidioidomycosis, Washington, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Oltean, Hanna N. ; Etienne, Kizee A. ; Roe, Chandler C. ; Gade, Lalitha ; McCotter, Orion Z. ; Engelthaler, David M. ; Litvintseva, Anastasia P.
• Description:
  Coccidioidomycosis is an emerging fungal infection in Washington, USA, and the epidemiology of the disease in this state is poorly understood. We used whole-genome sequencing to differentiate locally acquired cases in Washington on the basis of the previously identified phylogeographic population structure of Coccidioides spp. Clinical isolates from coccidioidomycosis cases involving possible Washington soil exposure were included. Of 17 human infections with epidemiologic evidence of possible local acquisition, 4 were likely locally acquired infections and 13 were likely acquired outside Washington. Isolates from locally acquired cases clustered within the previously established Washington clade of C. immitis. Genetic differences among these strains suggest multiple environmental reservoirs of C. immitis in the state.
• Subjects:
  Coccidioides Coccidioidomycosis Fungal Infections Fungi Public Health Research Surveillance Utility Of Whole-Genome Sequencing To Ascertain Locally Acquired Cases Of Coccidioidomycosis, Washington, USA Valley Fever Whole-genome Sequencing
• Source:
  Emerg Infect Dis. 25(3):501-506
• Pubmed ID:
  30789132
• Pubmed Central ID:
  PMC6390764
• Document Type:
  Journal Article
• Place as Subject:
  Washington
• Location:
  North America
• Volume:
  25
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:db569e02077ecc5479ec5b675dee6da6931be361f9e5f17b4e9ed294a0b41821
• Download URL:
  https://stacks.cdc.gov/view/cdc/76649/cdc_76649_DS1.pdf
• File Type:
  [PDF - 716.52 KB ]