Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010–2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bainomugisa, Arnold ; Pandey, Sushil ; Donnan, Ellen ; Simpson, Graham ; Foster, J’Belle ; Lavu, Evelyn ; Hiasihri, Stenard ; McBryde, Emma S. ; Moke, Rendi ; Vincent, Steven ; Sintchenko, Vitali ; Marais, Ben J. ; Coin, Lachlan J.M. ; Coulter, Christopher
• Description:
  In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.
• Subjects:
  Antitubercular Agents/pharmacology Bacterial Typing Techniques Emigration And Immigration Evolution, Molecular Genotype Geography History, 21st Century Humans Microbial Sensitivity Tests Mycobacterium Tuberculosis/drug Effects Mycobacterium Tuberculosis/genetics Mycobacterium Tuberculosis/isolation & Purification Synopsis Tuberculosis, Multidrug-Resistant/diagnosis Tuberculosis, Multidrug-Resistant/epidemiology Tuberculosis, Multidrug-Resistant/history Tuberculosis, Multidrug-Resistant/microbiology Whole Genome Sequencing

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• Source:
  Emerg Infect Dis. 25(3):406-415
• Pubmed ID:
  30789135
• Pubmed Central ID:
  PMC6390734
• Document Type:
  Journal Article
• Place as Subject:
  Australia ; Papua New Guinea
• Location:
  Oceania
• Volume:
  25
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b1c1edcb660ce1a5251bdb46972b9d8d8cfe9e2bc0fc678ef11727b7ae2c72cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/76646/cdc_76646_DS1.pdf
• File Type:
  [PDF - 1.75 MB ]