Multidrug-Resistant Tuberculosis in Europe, 2010–2011

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Günther, Gunar ; van Leth, Frank ; Alexandru, Sofia ; Altet, Neus ; Avsar, Korkut ; Bang, Didi ; Barbuta, Raisa ; Bothamley, Graham ; Ciobanu, Ana ; Crudu, Valeriu ; Davilovits, Manfred ; Dedicoat, Martin ; Duarte, Raquel ; Gualano, Gina ; Kunst, Heinke ; de Lange, Wiel ; Leimane, Vaira ; Magis-Escurra, Cecile ; McLaughlin, Anne-Marie ; Muylle, Inge ; Polcová, Veronika ; Pontali, Emanuele ; Popa, Christina ; Rumetshofer, Rudolf ; Skrahina, Alena ; Solodovnikova, Varvara ; Spinu, Victor ; Tiberi, Simon ; Viiklepp, Piret ; Lange, Christoph
• Corporate Authors:
  TBNET
• Description:
  Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to ≥1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.
• Subjects:
  Adult Antitubercular Agents Comorbidity Cross-Sectional Studies Female History, 21St Century Humans Incidence Male Microbial Sensitivity Tests Middle Aged Mycobacterium Tuberculosis Population Surveillance Risk Factors Tuberculosis, Multidrug-Resistant/Epidemiology Tuberculosis, Multidrug-Resistant/History Tuberculosis, Multidrug-Resistant/Microbiology

  More +
• Source:
  Emerg Infect Dis. 21(3):409-416.
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Europe
• Volume:
  21
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:83d214188cc55ff5ca562073f595a72b39afa2ff1421c049e0ce356f67c78ee9
• Download URL:
  https://stacks.cdc.gov/view/cdc/28108/cdc_28108_DS1.pdf
• File Type:
  [PDF - 495.89 KB ]