Multidrug-Resistant Tuberculosis in Europe, 2010–2011

Günther, Gunar; van Leth, Frank; Alexandru, Sofia; Altet, Neus; Avsar, Korkut; Bang, Didi; Barbuta, Raisa; Bothamley, Graham; Ciobanu, Ana; Crudu, Valeriu; Davilovits, Manfred; Dedicoat, Martin; Duarte, Raquel; Gualano, Gina; Kunst, Heinke; de Lange, Wiel; Leimane, Vaira; Magis-Escurra, Cecile; McLaughlin, Anne-Marie; Muylle, Inge; Polcová, Veronika; Pontali, Emanuele; Popa, Christina; Rumetshofer, Rudolf; Skrahina, Alena; Solodovnikova, Varvara; Spinu, Victor; Tiberi, Simon; Viiklepp, Piret; Lange, Christoph

doi:10.3201/eid2103.141343

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Multidrug-Resistant Tuberculosis in Europe, 2010–2011

Mar 2015
By Günther, Gunar ; van Leth, Frank ; Alexandru, Sofia ; ...
http://dx.doi.org/10.3201/eid2103.141343
Source: Emerg Infect Dis. 21(3):409-416.

[PDF-495.89 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Günther, Gunar ; van Leth, Frank ; Alexandru, Sofia ; Altet, Neus ; Avsar, Korkut ; ... More +

Günther, Gunar ; van Leth, Frank ; Alexandru, Sofia ; Altet, Neus ; Avsar, Korkut ; Bang, Didi ; Barbuta, Raisa ; Bothamley, Graham ; Ciobanu, Ana ; Crudu, Valeriu ; Davilovits, Manfred ; Dedicoat, Martin ; Duarte, Raquel ; Gualano, Gina ; Kunst, Heinke ; de Lange, Wiel ; Leimane, Vaira ; Magis-Escurra, Cecile ; McLaughlin, Anne-Marie ; Muylle, Inge ; Polcová, Veronika ; Pontali, Emanuele ; Popa, Christina ; Rumetshofer, Rudolf ; Skrahina, Alena ; Solodovnikova, Varvara ; Spinu, Victor ; Tiberi, Simon ; Viiklepp, Piret ; Lange, Christoph Less -
Corporate Authors:

TBNET
Description:

Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to ≥1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.
Subjects:

[+]

Adult Antitubercular Agents Comorbidity Cross-Sectional Studies Female History, 21St Century Humans Incidence Male Microbial Sensitivity Tests Middle Aged Mycobacterium Tuberculosis Population Surveillance Risk Factors Tuberculosis, Multidrug-Resistant/Epidemiology Tuberculosis, Multidrug-Resistant/History Tuberculosis, Multidrug-Resistant/Microbiology
Source:

Emerg Infect Dis. 21(3):409-416.
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

Europe
Volume:

21
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:83d214188cc55ff5ca562073f595a72b39afa2ff1421c049e0ce356f67c78ee9
Download URL:

https://stacks.cdc.gov/view/cdc/28108/cdc_28108_DS1.pdf
File Type:

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	14-1343-F.jpg	jpeg
	14-1343-Techapp-s1.pdf	pdf
	14-1343.nxml	txt
	license.txt	txt

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