Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015–2016

Karo-karo, Desniwaty; Bodewes, Rogier; Wibawa, Hendra; Artika, Made; Pribadi, Eko Sugeng; Diyantoro, D.; Pratomo, Widya; Sugama, Agus; Hendrayani, Nani; Indasari, Iin; Wibowo, Michael Haryadi; Muljono, David Handojo; Stegeman, Jan Arend; Koch, Guus

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Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015–2016

Supporting Files Public Domain

Mar 2019
By Karo-karo, Desniwaty ; Bodewes, Rogier ; Wibawa, Hendra

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Karo-karo, Desniwaty ; Bodewes, Rogier ; Wibawa, Hendra ; Artika, Made ; Pribadi, Eko Sugeng ; Diyantoro, D. ; Pratomo, Widya ; Sugama, Agus ; Hendrayani, Nani ; Indasari, Iin ; Wibowo, Michael Haryadi ; Muljono, David Handojo ; Stegeman, Jan Arend ; Koch, Guus
Description:

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
Subjects:
Source:

Emerg Infect Dis. 25(3):465-472
Pubmed ID:

30789142
Pubmed Central ID:

PMC6390736
Document Type:

Journal Article
Place as Subject:

Indonesia
Location:

Asia
Volume:

25
Issue:

3
Download URL:

https://stacks.cdc.gov/view/cdc/76630/cdc_76630_DS1.pdf
File Type:

[PDF - 3.69 MB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:356b630a18098a6f3f597b3e884db173b7881271e1857c3dbf1b4bacaa9faa10

File Language:

English

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