Potential Strategies for Clinical Translation of Repeated Cell Therapy

Details

• Alternative Title:
  Circ Res
• Personal Author:
  Vrtovec, Bojan ; Bolli, Roberto
• Description:
  Despite encouraging preclinical findings, clinical trials of repeated cell therapy are relatively scarce. As a result, the potential of this treatment paradigm remains to be assessed. We propose that a carefully planned clinical trial design using repeated cell dosing could lead to significant progress in the field of cell therapy.
• Keywords:
  Animals Cardiomyopathies Cell Differentiation Clinical Trials As Topic Dilated Cardiomyopathy Disease Models, Animal Graft Survival Heart Failure Humans Ischemic Heart Disease Myocardium Myocytes, Cardiac Paracrine Communication Recovery Of Function Regeneration Reoperation Repeated Cell Therapy Research Design Stem Cell Transplantation Translational Research, Biomedical Treatment Outcome Ventricular Dysfunction, Left Ventricular Function, Left

  More +
• Source:
  Circ Res. 124(5):690-692
• Pubmed ID:
  30817255
• Pubmed Central ID:
  PMC6400294
• Document Type:
  Journal Article
• Funding:
  R37 HL055757/HL/NHLBI NIH HHSUnited States/ ; R01 HL076794/HL/NHLBI NIH HHSUnited States/ ; R01 HL055757/HL/NHLBI NIH HHSUnited States/ ; R01 HL070897/HL/NHLBI NIH HHSUnited States/ ; H75 DP424252/DP/NCCDPHP CDC HHSUnited States/ ; P01 HL078825/HL/NHLBI NIH HHSUnited States/ ; UM1 HL113530/HL/NHLBI NIH HHSUnited States/ ; U24 HL094373/HL/NHLBI NIH HHSUnited States/ ; R01 HL068088/HL/NHLBI NIH HHSUnited States/
• Volume:
  124
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d5258c6daed69b92fbcb63836cc2a99c6f4dee37397c0fbd87f2c1a0e3b5740b
• Download URL:
  https://stacks.cdc.gov/view/cdc/76302/cdc_76302_DS1.pdf
• File Type:
  [PDF - 50.17 KB ]