Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  McElroy, Anita K. ; Shrivastava-Ranjan, Punya ; Harmon, Jessica R. ; Martines, Roosecelis B. ; Silva-Flannery, Luciana ; Flietstra, Timothy D. ; Kraft, Colleen S. ; Mehta, Aneesh K. ; Lyon, G. Marshall ; Varkey, Jay B. ; Ribner, Bruce S. ; Nichol, Stuart T. ; Zaki, Sherif R. ; Spiropoulou, Christina F.
• Description:
  Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Furthermore, substantial immunoreactivity of host tissues to a CD163-specific antibody, predominantly in areas of extensive immunostaining for Ebola virus antigens, was observed in fatal cases. These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD.
• Subjects:
  Activation Marker CD163 Ebolavirus Hemophagocytic Lymphohistiocytosis Hemorrhagic Fever, Ebola HLH Humans Hyperferritinemia Hypertriglyceridemia Inflammation Macrophage Macrophage Activation Syndrome MAS Research SCD25 SCD163 Severe Disease T Cells Viruses Zoonoses

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• Source:
  Emerg Infect Dis. 25(2):290-298
• Pubmed ID:
  30666927
• Pubmed Central ID:
  PMC6346465
• Document Type:
  Journal Article
• Funding:
  K08 AI119448/AI/NIAID NIH HHS/United States
• Volume:
  25
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dbbe9b521bb1f65871deb3a46184f0ce38c59c510797a9276663618215c1e20b
• Download URL:
  https://stacks.cdc.gov/view/cdc/75857/cdc_75857_DS1.pdf
• File Type:
  [PDF - 2.99 MB ]