Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1

McElroy, Anita K.; Shrivastava-Ranjan, Punya; Harmon, Jessica R.; Martines, Roosecelis B.; Silva-Flannery, Luciana; Flietstra, Timothy D.; Kraft, Colleen S.; Mehta, Aneesh K.; Lyon, G. Marshall; Varkey, Jay B.; Ribner, Bruce S.; Nichol, Stuart T.; Zaki, Sherif R.; Spiropoulou, Christina F.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1

Published Date:

Feb 2019

Source:

Emerg Infect Dis. 25(2):290-298

Language:

English

[PDF-2.99 MB]

Details:

Personal Authors:

McElroy, Anita K. ; Shrivastava-Ranjan, Punya ; Harmon, Jessica R. ; Martines, Roosecelis B. ; Silva-Flannery, Luciana ; ... More ▼

Keywords:

[+]

Pubmed ID:

30666927

Pubmed Central ID:

PMC6346465

Description:

Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Furthermore, substantial immunoreactivity of host tissues to a CD163-specific antibody, predominantly in areas of extensive immunostaining for Ebola virus antigens, was observed in fatal cases. These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Funding:

K08 AI119448/AI/NIAID NIH HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	18-1326-F1.gif	image/gif
	18-1326-F1.jpg	image/jpeg
	18-1326-F2.gif	image/gif
	18-1326-F2.jpg	image/jpeg
	18-1326-F3.gif	image/gif
	18-1326-F3.jpg	image/jpeg
	18-1326.nxml	text/xml

No Related Documents.

You May Also Like:

646. Activated Macrophages as Pathogenesis Factors in Ebola Virus Disease in Humans

Personal Author:

McElroy, Anita; Shrivastava-Ranjan, Punya; Harmon, Jessica; Martines, Roosecelis; Silva-Flannery, Luciana; Flietstra, Timothy; Kraft, Colleen; Mehta, Aneesh K; III, G Marshall Lyon; Varkey, Jay; Ribner, Bruce; Nichol, Stuart; Zaki, Sherif; Spiropoulou, Christina;

Conference Author:

IDWeek (2018 October 3-7 : San Franciso, CA)

Published:

Nov 26 2018

Source:

Open Forum Infect Dis. 2018; 5(Suppl 1):S234.

Description:

Background : Ebola virus disease (EVD) is associated with elevated cytokine levels that are more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of other inflammatory disorders, such as macrophage activation syndrome (M...

File Type:

[PDF - 225.18 KB]
Immunoactivating Peptide P4 Augments Alveolar Macrophage Phagocytosis in Two Diverse Human Populations

Personal Author:

Bangert, Mathieu; Wright, Adam K.; Rylance, Jamie; Kelly, Matthew J.; Wright, Angela D.; Carlone, George M.; Sampson, Jacquelyn S.; Rajam, Gowrisankar; Ades, Edwin W.; Kadioglu, Aras; Gordon, Stephen B.;

Published:

Jul 01 2013

Source:

Antimicrob Agents Chemother. 2013; 57(9):4566-4569.

Description:

New treatment strategies are urgently needed to overcome early mortality in acute bacterial infections. Previous studies have shown that administration of a novel immunoactivating peptide (P4) alongside passive immunotherapy prevents the onset of sep...

File Type:

[PDF - 439.59 KB]
Systemic Inflammation, Immune Activation and Impaired Lung Function among People Living with HIV in Rural Uganda

Personal Author:

North, Crystal M.; Muyanja, Daniel; Kakuhikire, Bernard; Tsai, Alexander C.; Tracy, Russell P.; Hunt, Peter W.; Kwon, Douglas S.; Christiani, David C.; Okello, Samson; Siedner, Mark J.;

Published:

Aug 15 2018

Source:

J Acquir Immune Defic Syndr. 78(5):543-548

Description:

Background : Although both chronic lung disease and HIV are inflammatory diseases common in sub-Saharan Africa, the relationship between systemic inflammation and lung function among people living with HIV (PLWH) in sub-Saharan Africa is not well des...

File Type:

[PDF - 76.07 KB]
A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma

Personal Author:

EPELDEGUI, Marta; MAGPANTAY, Larry; GUO, Yu; HALEC, Gordana; CUMBERLAND, William G.; YEN, Priscilla K.; MACATANGAY, Bernard; MARGOLICK, Joseph B.; ROSITCH, Anne F.; WOLINSKY, Steven; MARTINEZ-MAZA, Otoniel; HUSSAIN, Shehnaz K.;

Published:

Apr 24 2018

Source:

AIDS. 32(7):945-954

Description:

Chronic immune activation is a harbinger of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL), yet the underlying basis is unclear. Microbial translocation, the passage of microbial components from the gastrointestinal tract into the systemic circulati...

File Type:

[PDF - 497.15 KB]
The Janus kinase inhibitor Ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

Personal Author:

Haile, Woldeab B.; Gavegnano, Christina; Tao, Sijia; Jiang, Yong; Schinazi, Raymond F.; Tyor, William R.;

Published:

February 03 2016

Source:

Neurobiol Dis. 92(Pt B):137-143

Description:

A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal...

File Type:

[PDF - 608.12 KB]