Zika Virus IgM Detection and Neutralizing Antibody Profiles 12–19 Months after Illness Onset

Griffin, Isabel; Martin, Stacey W.; Fischer, Marc; Chambers, Trudy V.; Kosoy, Olga; Falise, Alyssa; Ponomareva, Olga; Gillis, Leah D.; Blackmore, Carina; Jean, Reynald

i

Zika Virus IgM Detection and Neutralizing Antibody Profiles 12–19 Months after Illness Onset

Supporting Files Public Domain

Feb 2019
By Griffin, Isabel ; Martin, Stacey W. ; Fischer, Marc ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Griffin, Isabel ; Martin, Stacey W. ; Fischer, Marc ; Chambers, Trudy V. ; Kosoy, Olga ; Falise, Alyssa ; Ponomareva, Olga ; Gillis, Leah D. ; Blackmore, Carina ; Jean, Reynald
Description:

Data on the duration of detectable Zika virus-specific IgM in infected persons are limited. Neutralizing antibody cross-reactivity occurs between Zika virus and related flaviviruses, but the degree to which this confounds diagnosis is uncertain. We tested serum specimens collected 12-19 months after illness onset from patients with confirmed Zika virus disease for Zika virus IgM and Zika virus and dengue virus neutralizing antibodies. Among 62 participants, 45 (73%) had detectable Zika virus IgM and 12 (19%) had an equivocal result. Although all patients tested had Zika virus neutralizing antibodies, 39 (63%) also had neutralizing antibodies against dengue virus; of those, 12 (19%) had <4-fold difference between Zika virus and dengue virus titers, and 5 (8%) had dengue virus titer >4-fold higher than Zika virus titer. Prolonged detection of IgM and neutralizing antibody cross-reactivity make it difficult to determine the timing of Zika virus infection and differentiate between related flaviviruses.
Subjects:

Flaviviruses IgM Immunoglobulin MAC-ELISA Neutralizing Antibodies Research Viruses Zika Virus Zika Virus IgM Detection And Neutralizing Antibody Profiles 12–19 Months After Illness Onset
Source:

Emerg Infect Dis. 25(2):299-303
Pubmed ID:

30666931
Pubmed Central ID:

PMC6346474
Document Type:

Journal Article
Place as Subject:

Florida
Location:

North America
Volume:

25
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c21ad9fbaf7683f3deb5808c7799fe2ad30adc741a57a8f46a27812bff843d79
Download URL:

https://stacks.cdc.gov/view/cdc/75854/cdc_75854_DS1.pdf
File Type:

[PDF - 437.06 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.