Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Collins, Matthew H.; McGowan, Eileen; Jadi, Ramesh; Young, Ellen; Lopez, Cesar A.; Baric, Ralph S.; Lazear, Helen M.; de Silva, Aravinda M.

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Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Supporting Files Public Domain

May 2017
By Collins, Matthew H. ; McGowan, Eileen ; Jadi, Ramesh ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Collins, Matthew H. ; McGowan, Eileen ; Jadi, Ramesh ; Young, Ellen ; Lopez, Cesar A. ; Baric, Ralph S. ; Lazear, Helen M. ; de Silva, Aravinda M.
Description:

Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV infection. Whether this finding is true in late DENV convalescence (>6 months after infection) is unknown. We studied late convalescent serum samples from persons with prior DENV or Zika virus exposure. Despite extensive cross-reactivity in IgG binding, Zika virus neutralization was not observed among primary DENV infections. We observed low-frequency (23%) Zika virus cross-neutralization in repeat DENV infections. DENV-immune persons who had Zika virus as a secondary infection had distinct populations of antibodies that neutralized DENVs and Zika virus, as shown by DENV-reactive antibody depletion experiments. These data suggest that most DENV infections do not induce durable, high-level Zika virus cross-neutralizing antibodies. Zika virus-specific antibody populations develop after Zika virus infection irrespective of prior DENV immunity.
Subjects:

Cross-neutralizing Antibodies Dengue Virus DENV Flaviviruses Lack Of Durable Cross-Neutralizing Antibodies Against Zika Virus From Dengue Virus Infection Research Vector-borne Infections Viruses Zika Virus
Source:

Emerg Infect Dis. 23(5):773-781.
Pubmed ID:

28418292
Pubmed Central ID:

PMC5403059
Document Type:

Journal Article
Volume:

23
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:0f96c238a2a4bdab90f9f117ba9618ff375be35f8cd4f58dfca45bd36af9751c
Download URL:

https://stacks.cdc.gov/view/cdc/45624/cdc_45624_DS1.pdf
File Type:

[PDF - 1.72 MB ]

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