HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Opollo, V. S. ; Wu, X. ; Hughes, M. D. ; Swindells, S. ; Gupta, A. ; Hesseling, A. ; Churchyard, G. ; Kim, S. ; Lando, R. ; Dawson, R. ; Mave, V. ; Mendoza, A. ; Gonzales, P. ; Kumarasamy, N. ; von Groote-Bidlingmaier, F. ; Conradie, F. ; Shenje, J. ; Fontain, S. N. ; Garcia-Prats, A. ; Asmelash, A. ; Nedsuwan, S. ; Mohapi, L. ; Mngqibisa, R. ; Garcia Ferreira, A. C. ; Okeyo, E. ; Naini, L. ; Jones, L. ; Smith, B. ; Shah, N. S.
• Description:
  SETTING:
  
  The household contacts (HHCs) of multidrug-resistant tuberculosis (MDR-TB) index cases are at high risk of tuberculous infection and disease progression, particularly if infected with the human immunodeficiency virus (HIV). HIV testing is important for risk assessment and clinical management.
  
  METHODS:
  
  This was a cross-sectional, multi-country study of adult MDR-TB index cases and HHCs. All adult and child HHCs were offered HIV testing if never tested or if HIV-negative > 1 year previously when last tested. We measured HIV testing uptake and used logistic regression to evaluate predictors.
  
  RESULTS
  
  A total of 1007 HHCs of 284 index cases were enrolled in eight countries. HIV status was known at enrolment for 226 (22%) HHCs; 39 (4%) were HIV-positive. HIV testing was offered to 769 (98%) of the 781 remaining HHCs; 544 (71%) agreed to testing. Of 535 who were actually tested, 26 (5%) were HIV-infected. HIV testing uptake varied by site (median 86%, range 0–100%; P<0.0001), and was lower in children aged ,18 years than in adults (59% vs. 78%; adjusted for site P < 0.0001).
  
  CONCLUSIONS:
  
  HIV testing of HHCs of MDR-TB index cases is feasible and high-yield, with 5% testing positive. Reasons for low test uptake among children and at specific sites—including sites with high HIV prevalence—require further study to ensure all persons at risk for HIV are aware of their status.
  
  
• Subjects:
  Adolescent Adult Article Barriers Child Cross-Sectional Studies Developing Countries Family Characteristics Female HCT Testing HIV Infections Humans Internationality Logistic Models Male Mass Screening Middle Aged Patient Acceptance Of Health Care Prevalence Risk Factors Severity Of Illness Index Tuberculosis, Multidrug-Resistant Willingness To Test Young Adult

  More +
• Source:
  Int J Tuberc Lung Dis. 22(12):1443-1449
• Pubmed ID:
  30606316
• Pubmed Central ID:
  PMC6364692
• Document Type:
  Journal Article
• Funding:
  UM1 AI069456/AI/NIAID NIH HHS/United States ; U01 AI069463/AI/NIAID NIH HHS/United States ; UM1 AI068632/AI/NIAID NIH HHS/United States ; UM1 AI068634/AI/NIAID NIH HHS/United States ; U01 AI069521/AI/NIAID NIH HHS/United States ; UM1 AI106701/AI/NIAID NIH HHS/United States ; UM1 AI069521/AI/NIAID NIH HHS/United States ; HHSN275200800001I/HD/NICHD NIH HHS/United States ; UM1 AI106716/AI/NIAID NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; UM1 AI069453/AI/NIAID NIH HHS/United States ; PEPFAR/PEPFAR/United States ; UM1 AI069463/AI/NIAID NIH HHS/United States ; UM1 AI068616/AI/NIAID NIH HHS/United States ; UM1 AI068636/AI/NIAID NIH HHS/United States ; UM1 AI069418/AI/NIAID NIH HHS/United States
• Volume:
  22
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:46047fb6428010424a9c0da8b7ea3f04e8d781646260d2a183a74ffd1d933405
• Download URL:
  https://stacks.cdc.gov/view/cdc/75831/cdc_75831_DS1.pdf
• File Type:
  [PDF - 556.80 KB ]