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Invasive Haemophilus influenzae Serotype a Infection in Children: Clinical Description of an Emerging Pathogen — Alaska, 2002–2014
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April 2018
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Source: Pediatr Infect Dis J. 37(4):298-303
[PDF-86.11 KB]
Details:
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Alternative Title:Pediatr Infect Dis J
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Description:Background
Invasive infections from Haemophilus influenzae serotype a (Hia) have been reported with increasing frequency, especially among indigenous populations. However there are limited population-based-studies of clinical severity. We studied invasive Hia infections in Alaska to determine clinical characteristics, mortality, and sequelae.
Methods
We defined an invasive Hia infection as the first detection of Hia from a usually sterile site in a child <10 years of age from Alaska. We identified cases using the Alaska Invasive Bacterial Diseases Surveillance System and reviewed medical charts up to 2 years after reported illness.
Results
We identified invasive Hia infections in 36 children, 28 (78%) <1 year old, 34 (94%) living in an Alaskan village, and 25 (69%) without documented underlying illness. Overlapping clinical presentations included meningitis in 15 children (42%); bacteremia and pneumonia in 10 children (28%); and bone, joint or soft tissue infections in 10 children (22%). In four other children, no source of invasive infection was identified. Intensive care was provided for 11 children (31%); 12 children (33%) required surgical intervention. One year after infection, 4 children (11%) had died from Hia, and 5 children (14%) had ongoing neurologic sequelae.
Conclusions
Invasive Hia infections in Alaska occurred predominantly in Alaska Native infants in rural communities. Although one-third of children had pre-existing conditions, most cases occurred without known comorbidity. Clinical syndromes were frequently severe. One year after infection, one in four children had either died or had neurologic sequelae. An effective vaccine would prevent significant morbidity and mortality in affected populations.
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Pubmed ID:29189672
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Pubmed Central ID:PMC6362456
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Volume:37
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Issue:4
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