Racial disparities in invasive Haemophilus influenzae disease — United States, 2008–2017

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Brown, Nicole E. ; Blain, Amy E. ; Burzlaff, Kari ; Harrison, Lee H. ; Petit, Susan ; Schaffner, William ; Smelser, Chad ; Thomas, Ann ; Triden, Lori ; Watt, James P. ; Pondo, Tracy ; Whaley, Melissa J. ; Hu, Fang ; Wang, Xin ; Oliver, Sara ; Soeters, Heidi M.
  More +
• Description:
  Background: ; Since the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines in the United States, invasive H. influenzae disease (Hi) epidemiology has changed and racial disparities have not been recently described. ; Methods: ; Active population- and laboratory-based surveillance for Hi was conducted through Active Bacterial Core surveillance (ABCs) at 10 U.S. sites. Data from 2008–2017 was used to estimate projected nationwide annual incidence in cases/100,000. ; Results: ; During 2008–2017, ABCs identified 7379 Hi cases. Of 6705 (90.9%) patients with reported race, 76.2% were White, 18.6% were Black, 2.8% were Asian/Pacific Islander (PI), and 2.4% were American Indian and Alaska Native (AI/AN). Nationwide annual incidence was 1.8 cases/100,000. By race, incidence was highest among AI/AN populations (3.1) and lowest among Asian/PI populations (0.8). Nontypeable Hi (NTHi) caused the largest incidence within all races (1.3), with no striking disparities identified. Among AI/AN children aged <5 years, incidence of Hi serotype a (Hia) was 16.7 times higher and Hib incidence was 22.4 times higher than among White children. Though Hia incidence was lower among White and Black populations compared to AI/AN, Hia incidence increased 13.6% annually among White children and 40.4% annually among Black children aged <5 years. ; Conclusions: ; While NTHi causes the largest Hi burden overall, AI/AN populations experience disproportionately high rates of Hia and Hib, with the greatest disparity among AI/AN children aged <5 years. Prevention tools are needed to reduce disparities affecting AI/AN children and address increasing Hia incidence in other communities.
• Subjects:
  • Child
  • Haemophilus Infections
  • Haemophilus Vaccines
  • Haemophilus influenzae
  • Haemophilus influenzae type b
  • Humans
  • Incidence
  • Infant
  • Serogroup
  • United States
• Keywords:
  • Haemophilus influenzae
  • Haemophilus influenzae vaccines
  • epidemiology
  • public health surveillance
  • minority health
• Source:
  Clin Infect Dis. 73(9):1617-1624
• Pubmed ID:
  33993217
• Pubmed Central ID:
  PMC11307574
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; CDC-RFA-CK12-120205CONT16/CC/CDC HHSUnited States/
• Volume:
  73
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/159770/cdc_159770_DS1.pdf
• File Type:
  [PDF - 1.11 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3931b6f6684a07a5d254a31c7017516f39cdded4420fea4d4b2a3677bc5ce03b68526b26e09b5ca5462f75b763023a17c2e79e8bab86cf0d49eb546495b23eeb