Genetic considerations in human cancer incidence.

Details

• Alternative Title:
  Public Health Rep
• Personal Author:
  Thurmon, T F ; Robertson, K P
• Description:
  Analysis by the methods of genetic demography can offer plausible explanations for the unusual distribution of cancer in an area of high incidence. The important demographic characteristics include inbreeding, founder effect, and racial admixture. Inbreeding would elevate cancer incidence if autosomal recessive genes played a role in cancer etiology. Founder effect would limit this phenomenon to those recessive genes observed in the founding group and result in a cancer spectrum different from that of the surrounding populations. The preference of a racially admixed group for classification as white could result in an excess of cancer patients being classified as white. The population groups in southern Louisiana typify the kind of "human genetics laboratory" that inbred groups offer to investigators of the genetic aspects of cancer.
• Subjects:
  Adult Chromosome Aberrations Chromosome Disorders Consanguinity Female Genes, Recessive Genetics, Population Humans Inbreeding Male Neoplasms Racial Groups

  More +
• Source:
  Public Health Rep. 94(5):471-476
• Pubmed ID:
  482581
• Pubmed Central ID:
  PMCnull
• Document Type:
  Journal Article
• Place as Subject:
  Louisiana
• Volume:
  94
• Issue:
  5
• Collection(s):
  Public Health Reports
• Main Document Checksum:
  urn:sha256:41d4273b0b99fa6b6073a83310b09a46557b30646c1788a577e2453ff1f6b4d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/65591/cdc_65591_DS1.pdf
• File Type:
  [PDF - 965.58 KB ]