The risks and benefits of long-term estrogen replacement therapy.

Barrett-Connor, E L

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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The risks and benefits of long-term estrogen replacement therapy.

1989 Sep-Oct
By Barrett-Connor, E L
Source: Public Health Rep. 104(Suppl):62-65

English

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Details:

Alternative Title:

Public Health Rep
Personal Author:

Barrett-Connor, E L
Description:

Estrogen replacement therapy (ERT) for postmenopausal women greatly reduces the risk of osteoporotic fractures, but carries an increased risk of endometrial cancer. This risk can be reduced by the addition of progestin, which does not interfere with the osteoporotic benefit of estrogen. Although long-term use data are few, there is presently little evidence for an increase or decrease in breast cancer risk associated with estrogen by itself (unopposed estrogen), or estrogen plus progestin. In contrast, a large body of evidence suggests that unopposed estrogen significantly reduces the risk of cardiovascular disease; there is no evidence that this benefit will persist when a progestin is added. The preferred method of estrogen replacement therapy, to prevent osteoporosis in a postmenopausal woman with an intact uterus, should be chosen with these different risks and benefits in mind.
Subjects:

[+]

Adult Aged Estrogen Replacement Therapy Female Humans Middle Aged Osteoporosis, Postmenopausal Progestins Research Article Risk
Source:

Public Health Rep. 104(Suppl):62-65
Pubmed ID:

2517703
Pubmed Central ID:

PMCnull
Document Type:

Journal Article
Volume:

104
Collection(s):

Public Health Reports
Main Document Checksum:

[+]

urn:sha256:ad3935e96ea0c19fda53e98d0d6e48b883f50f79c830ec9fe534749e08ba5b1a
Download URL:

https://stacks.cdc.gov/view/cdc/63417/cdc_63417_DS1.pdf
File Type:

[PDF-1.02 MB]