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Research on alcohol metabolism among Asians and its implications for understanding causes of alcoholism.
  • Published Date:
    1989 Nov-Dec
  • Source:
    Public Health Rep. 104(6):615-620
  • Language:
    English
Filetype[PDF-1.05 MB]


Details:
  • Alternative Title:
    Public Health Rep
  • Personal Author:
    Suddendorf, R F
  • Description:
    Research into the causes of alcoholism is a relatively recent scientific endeavor. One area of study which could lead to better understanding of the disease is the possibility of a genetic predisposition to alcoholism. Recent work has demonstrated that people have varying complements of enzymes to metabolize alcohol. Current knowledge is examined about the influence of various ethanol metabolizing enzymes on alcohol consumption by Asians and members of other ethnic groups. The two principal enzymes involved in ethanol oxidative metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). ADH is responsible for the metabolism of ethanol to acetaldehyde. ALDH catalyzes the conversion of acetaldehyde to acetate. The different isozymes account for the diversity of alcohol metabolism among individuals. An isozyme of ADH (beta 2 beta 2) is found more frequently in Asians than in whites, and an ALDH isozyme (ALDH2), although present in Asians, often is in an inactive form. The presence of an inactive form of ALDH2 is thought to be responsible for an increase in acetaldehyde levels in the body. Acetaldehyde is considered responsible for the facial flushing reaction often observed among Asians who have consumed alcohol. A dysphoric reaction to alcohol, producing uncomfortable sensations, is believed to be a response to deter further consumption. Although the presence of an inactive ALDH2 isozyme may serve as a deterrent to alcohol consumption, its presence does not fully explain the levels of alcohol consumption by those with the inactive isozyme. Other conditions, such as social pressure, and yet undetermined biological factors, may play a significant role in alcohol consumption.

  • Subject:
  • Pubmed ID:
    2511595
  • Pubmed Central ID:
    PMCnull
  • Document Type:
    Journal Article
  • Collection(s):
    Public Health Reports
  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
    1. Improving the health of minorities.
      Personal Author:
      Mason, J O
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):523-525
      File Type:
      Filetype[PDF - 521.49 KB]
    2. Sign ordinance aimed at alcohol use by young adults in two Florida countries.
      Personal Author:
      Cleary, D
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):525-526
      File Type:
      Filetype[PDF - 324.19 KB]
    3. Meeting minority health needs through special MCH projects.
      Personal Author:
      Hutchins, V; Walch, C;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):621-626
      Description:
      The maternal and child health programs of the Public Health Service have always been directed to minority populations; however, the recent surges of immigrants from Asian and Central American countries have caused the agency to appraise its efforts t...
      File Type:
      Filetype[PDF - 1.30 MB]
    4. Black-on-black homicide: Kansas City's response.
      Personal Author:
      Mitchell, M A; Daniels, S;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):605-608
      Description:
      In many metropolitan areas, homicide continues to be the scourge of black Americans despite increasing awareness of the overrepresentation of blacks among victims and perpetrators. The risk of being a homicide victim among black males is so high that...
      File Type:
      Filetype[PDF - 716.18 KB]
    5. Public Health Reports ; v. 104, no. 6 : table of contents
      Published Date:
      Nov-Dec 1989
      Source:
      Public Health Rep. 104(6)
      File Type:
      Filetype[PDF - 483.41 KB]
    6. An urban community-based cancer prevention screening and health education intervention in Chicago.
      Personal Author:
      Lacey, L P; Phillips, C W; Ansell, D; Whitman, S; Ebie, N; Chen, E;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):536-541
      Description:
      Most types of cancer are disproportionately present in black populations. Among all ethnic and racial groups, black people have the highest incidence of all types of cancer combined, experiencing the highest mortality and the worst survival rate. A m...
      File Type:
      Filetype[PDF - 1.20 MB]
    7. Participation rates, weight loss, and blood pressure changes among obese women in a nutrition-exercise program.
      Personal Author:
      Lasco, Richard A.; Curry, Robert H.; Dickson, V. Joann; Powers, Judy; Menes, Sandra; Merritt, Robert K.;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):640-646
      Description:
      Since 1985, a black urban community in Atlanta has planned, implemented, and evaluated a cardiovascular risk reduction project. The Community Health Assessment and Promotion Project (CHAPP) was developed to reduce the high incidence of cardiovascular...
      File Type:
      Filetype[PDF - 1.46 MB]
    8. PHS grants for minority group HIV infection education and prevention efforts.
      Personal Author:
      Bowles, J; Robinson, W A;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):552-559
      Description:
      The Office of Minority Health (OMH) was established in December 1985 in response to recommendations developed by the Secretary's Task Force on Black and Minority Health. Originally, OMH's mission emphasized six health problems identified by the Task ...
      File Type:
      Filetype[PDF - 1.71 MB]
    9. Mexican American and white American school dropouts' drug use, health status, and involvement in violence.
      Personal Author:
      Chavez, E L; Edwards, R; Oetting, E R;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):594-604
      Description:
      A group of Mexican American and white American school dropouts were compared with a control group and a group of academically at-risk students in three locations in the Southwest. The sample group consisted of school dropouts and comparison subjects ...
      File Type:
      Filetype[PDF - 2.01 MB]
    10. Reaching Hispanics with messages to prevent alcohol and other drug abuse.
      Personal Author:
      Johnson, E M; Delgado, J L;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):588-594
      Description:
      Hispanics are often labeled a "hard-to-reach" population in the context of health communications, yet there are indicators that corporate interests increasingly are reporting successes in designing advertising and promotional campaigns targeting Hisp...
      File Type:
      Filetype[PDF - 1.36 MB]
    11. Tribal differences in diabetes: prevalence among American Indians in New Mexico.
      Personal Author:
      Carter, J; Horowitz, R; Wilson, R; Sava, S; Sinnock, P; Gohdes, D;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):665-669
      Description:
      The prevalence of diagnosed diabetes among American Indians in New Mexico with varied genetic and cultural backgrounds is reported. Utilizing community-based registries, the prevalence in persons ages 35 years and older ranged from 9.8 percent among ...
      File Type:
      Filetype[PDF - 895.58 KB]
    12. Detroit's avoidable mortality project: breast cancer control for inner-city women.
      Personal Author:
      Burack, R C; Gimotty, P A; Stengle, W; Eckert, D; Warbasse, L; Moncrease, A;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):527-535
      Description:
      Mammography remains substantially under-used in low-income minority populations despite its well-established efficacy as a means of breast cancer control. The Metropolitan Detroit Avoidable Mortality Project is a 2-year controlled clinical trial of c...
      File Type:
      Filetype[PDF - 2.00 MB]
    13. Public Health Rep ; v. 104, no. 6 : Masthead
      Published Date:
      Nov-Dec 1989
      Source:
      Public Health Rep. 104(6)
      File Type:
      Filetype[PDF - 2.49 MB]
    14. Preventing baby bottle tooth decay in American Indian and Alaska native communities: a model for planning.
      Personal Author:
      Bruerd, B; Kinney, M B; Bothwell, E;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):631-640
      File Type:
      Filetype[PDF - 2.67 MB]
    15. Sexually transmitted diseases and native Americans: trends in reported gonorrhea and syphilis morbidity, 1984-88.
      Personal Author:
      Toomey, K E; Oberschelp, A G; Greenspan, J R;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):566-572
      Description:
      Native Americans experienced higher reported gonorrhea and syphilis morbidity than did non-Native Americans from 1984 through 1988 in 13 States with large Native American populations. Gonorrhea rates among American Indians and Alaska Natives were app...
      File Type:
      Filetype[PDF - 1.60 MB]
    16. Cancer in Alaskan Indians, Eskimos, and Aleuts, 1969-83: implications for etiology and control.
      Personal Author:
      Lanier, A P; Bulkow, L R; Ireland, B;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):658-664
      Description:
      The authors collected and analyzed cancer incidence data for Alaska Natives (Indians, Eskimos, and Aleuts) for the 15-year period 1969-83 by ethnic and linguistic groups. Compared with U.S. whites, observed-to-expected ratios are high in more than on...
      File Type:
      Filetype[PDF - 2.12 MB]
    17. A psychosocial approach to smoking prevention for urban black youth.
      Personal Author:
      Botvin, G J; Batson, H W; Witts-Vitale, S; Bess, V; Baker, E; Dusenbury, L;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):573-582
      Description:
      Despite the high rates of smoking-related cancers among black Americans, little is known about the type of smoking prevention program that might be effective with black youth. The current study pilot-tested a promising smoking prevention approach to ...
      File Type:
      Filetype[PDF - 1.77 MB]
    18. Tuberculosis: an increasing problem among minorities in the United States.
      Personal Author:
      Snider, D E; Salinas, L; Kelly, G D;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):646-653
      Description:
      Although the number of tuberculosis cases reported annually in the United States has decreased markedly during the past three and a half decades, the decrease among whites has been considerably greater than among nonwhites. As a result of this wideni...
      File Type:
      Filetype[PDF - 1.98 MB]
    19. Using 1990 national MCH objectives to assess health status and risk in an American Indian community.
      Personal Author:
      Campbell, Bruce C.; Kimball, Ernest H.; Helgerson, Steven D.; Alexander, Isole L.; Goldberg, Howard I.;
      Published Date:
      1989 Nov-Dec
      Source:
      Public Health Rep. 104(6):627-631
      Description:
      The authors used data from birth records to assess changes in health risks and health status of American Indians (AI) living in Umatilla County, OR, from 1973 to 1986. They compared the AI health risks and health status with those of other persons (n...
      File Type:
      Filetype[PDF - 1.15 MB]
    20. Public Health Reports ; v. 104 , no. 6 : cover
      Published Date:
      Nov-Dec 1989
      Source:
      Public Health Rep 104 (6)
      File Type:
      Filetype[PDF - 594.73 KB]
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