Progress in drug therapies for HIV infection.
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Progress in drug therapies for HIV infection.
  • Published Date:

    1988 May-Jun

  • Source:
    Public Health Rep. 103(3):224-229
  • Language:
    English
Filetype[PDF-973.22 KB]


Details:
  • Alternative Title:
    Public Health Rep
  • Personal Author:
  • Description:
    The discovery of effective therapies for HIV requires a fundamental knowledge of retroviral infections. Research by the Public Health Service and collaborating organizations on oncogenic viruses, including retroviruses, has provided much of the basic understanding of retroviruses in general and anti-retroviral therapeutic strategies in particular. Early work by the Viral Cancer and Developmental Therapeutic Programs of the National Cancer Institute and the Intramural Research Program of the National Institute of Allergy and Infectious Diseases has contributed much of the current understanding of AIDS and its therapy. This paper describes the progress that has been made in the treatment of AIDS and the programs that have been created to develop future therapies. These programs include efforts to screen existing compounds for activity against HIV, to design new anti-HIV therapies, and to test potential agents in controlled clinical trials. As a result of these activities, researchers have identified one drug, AZT, that has proven effective in prolonging the lives of some patients with AIDS, and are developing several other promising compounds. The key question no longer is whether HIV infection can be treated, but what is the best and fastest way to develop new therapies and improve existing ones.
  • Subject:
  • Pubmed ID:
    3131811
  • Pubmed Central ID:
    PMCnull
  • Document Type:
    Journal Article
  • Collection(s):
    Public Health Reports
  • Main Document Checksum:
  • File Type:
  • Supporting Files:
    No Additional Files
    1. Filetype[PDF - 1.26 MB]
      Personal Author:
      Sundwall, D N; Bailey, D;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):293-298
      Description:
      The Health Resources and Services Administration (HRSA), one of the seven agencies of the Public Health Service, is working to meet some of the resource and patient service needs engendered by the epidemic of acquired immune deficiency syndrome (AIDS...
      File Type:
      Filetype[PDF - 1.26 MB]
    2. Filetype[PDF - 1.08 MB]
      Personal Author:
      Kawata, P A; Andriote, J M;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):299-304
      Description:
      Because of the variety of needs engendered by AIDS, a broadbased response to the epidemic is warranted. The traditional medical model, with its emphasis on inpatient hospital care, is expensive and fails to address other needs of people with AIDS (PW...
      File Type:
      Filetype[PDF - 1.08 MB]
    3. Filetype[PDF - 731.67 KB]
      Personal Author:
      Samuels, M E; Mann, J; Koop, C E;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):221-223
      Description:
      The World Health Organization (WHO) estimates that the world total of AIDS cases will reach 300,000 by the end of 1988 and 500,000 to 3 million over the next 5 years. AIDS is of special concern to developing countries with their limited, stressed hea...
      File Type:
      Filetype[PDF - 731.67 KB]
    4. Filetype[PDF - 857.15 KB]
      Personal Author:
      Young, F E
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):242-245
      Description:
      The Food and Drug Administration has instituted several pro-active measures to expedite the review of treatments, diagnostics, and vaccines for AIDS and related conditions. In particular, the agency has established a special designation--1-AA--for a ...
      File Type:
      Filetype[PDF - 857.15 KB]
    5. Filetype[PDF - 870.04 KB]
      Personal Author:
      Spero, J R
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):278-281
      Description:
      Nursing students, as future health care providers, need comprehensive instruction about AIDS--the many manifestations of both the disease itself and the pandemic. As health educators and practitioners, nurses play a major role in safeguarding the hea...
      File Type:
      Filetype[PDF - 870.04 KB]
    6. Filetype[PDF - 908.21 KB]
      Personal Author:
      Weiss, R; Thier, S O;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):289-292
      Description:
      In 1985 the Institute of Medicine, National Academy of Sciences devoted its annual meeting to an exploration of acquired immunodeficiency syndrome (AIDS). The questions raised at the meeting propelled the IOM/NAS to initiate an assessment of the dime...
      File Type:
      Filetype[PDF - 908.21 KB]
    7. Filetype[PDF - 1.41 MB]
      Personal Author:
      Richland, J H
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):267-272
      Description:
      State health agencies have assumed a leadership role in responding to the major public health issues raised by the AIDS epidemic. Directors of State health agencies (State health officers) have asserted their influence at the national level as well a...
      File Type:
      Filetype[PDF - 1.41 MB]
    8. Filetype[PDF - 1.16 MB]
      Personal Author:
      Fauci, A S; Fischinger, P J;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):230-236
      Description:
      The development of a safe and effective vaccine against infection by the human immunodeficiency virus (HIV) is of paramount importance to the prevention of AIDS worldwide. Although a great deal has been learned about HIV in a few short years, the dev...
      File Type:
      Filetype[PDF - 1.16 MB]
    9. Filetype[PDF - 1.54 MB]
      Personal Author:
      Petricciani, J C; Epstein, J S;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):236-241
      Description:
      Present safeguards for the blood supply consist of three tiers of protection: donor deferral based on a donor's history of risk factors, confidential exclusion of blood units from donors with self-admitted risk factors, and testing of the blood itsel...
      File Type:
      Filetype[PDF - 1.54 MB]
    10. Filetype[PDF - 1.36 MB]
      Personal Author:
      Schuster, C R
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):261-266
      Description:
      Research programs of the National Institute on Drug Abuse take a broad approach to investigating the problems of intervention in intravenous drug use and its relation to the AIDS epidemic. Current prevention strategies are directed to reducing the ra...
      File Type:
      Filetype[PDF - 1.36 MB]
    11. Filetype[PDF - 912.93 KB]
      Personal Author:
      Windom, R E
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):209-210
      File Type:
      Filetype[PDF - 912.93 KB]
    12. Filetype[PDF - 327.56 KB]
      Personal Author:
      Bowen, O R
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):211-212
      File Type:
      Filetype[PDF - 327.56 KB]
    13. Filetype[PDF - 4.80 MB]
      Published Date:
      May-Jun 1988
      Source:
      Public Health Rep. 103(3)
      File Type:
      Filetype[PDF - 4.80 MB]
    14. Filetype[PDF - 803.85 KB]
      Personal Author:
      McCarthy, C
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):273-277
      Description:
      The American Hospital Association (AHA) has taken a leadership role in assisting health care providers in dealing effectively with the challenges of AIDS. Early work focused on preventing infection in the health care setting with the use of the Cente...
      File Type:
      Filetype[PDF - 803.85 KB]
    15. Filetype[PDF - 2.12 MB]
      Personal Author:
      Hellinger, F J
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):309-319
      Description:
      The personal medical care costs of those diagnosed with acquired immunodeficiency syndrome (AIDS) in 1988 are forecast to be $2.2 billion, an amount that will increase to $4.5 billion in 1991. This is the first study to include the cost of purchasing...
      File Type:
      Filetype[PDF - 2.12 MB]
    16. Filetype[PDF - 2.01 MB]
      Personal Author:
      Macher, A M
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):246-254
      Description:
      The acquired immunodeficiency syndrome (AIDS) is a devastating new disease caused by the human immunodeficiency virus (HIV). This retrovirus causes profound immunoincompetence in its infected hosts, who are thereafter susceptible to develop myriad se...
      File Type:
      Filetype[PDF - 2.01 MB]
    17. Filetype[PDF - 898.55 KB]
      Personal Author:
      Roper, William L.; Winkenwerder, William;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):305-308
      Description:
      An estimated 40 percent of the nation's 55,000 persons with acquired immunodeficiency syndrome (AIDS) have received care under the Medicaid Program, which is administered by the Health Care Financing Administration (HCFA) and funded jointly by the Fe...
      File Type:
      Filetype[PDF - 898.55 KB]
    18. Filetype[PDF - 1.18 MB]
      Personal Author:
      Hotchkiss, W S
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):282-288
      Description:
      Since the identification of acquired immunodeficiency syndrome (AIDS) in 1981 as a distinct disease entity, the number of AIDS cases has steadily increased in the United States and throughout the world. Although the primary etiologic agent of AIDS, h...
      File Type:
      Filetype[PDF - 1.18 MB]
    19. Filetype[PDF - 558.91 KB]
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):325-327
      File Type:
      Filetype[PDF - 558.91 KB]
    20. Filetype[PDF - 1.54 MB]
      Personal Author:
      Dondero, Timothy J.; Pappaioanou, Marguerite; Curran, James W.;
      Published Date:
      1988 May-Jun
      Source:
      Public Health Rep. 103(3):213-220
      Description:
      A comprehensive, multifaceted approach to HIV surveillance is needed to provide the information necessary for public health management and policy. Because HIV infection is not readily or uniformly ascertained, survey methods and sentinel surveillance...
      File Type:
      Filetype[PDF - 1.54 MB]

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