Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children

Details

• Alternative Title:
  J Autism Dev Disord
• Personal Author:
  Rubenstein, Eric ; Young, Jessica C. ; Croen, Lisa A. ; DiGuiseppi, Carolyn ; Dowling, Nicole F. ; Lee, Li-Ching ; Schieve, Laura ; Wiggins, Lisa D. ; Daniels, Julie
• Description:
  Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
• Subjects:
  Analgesics, Opioid Autism Spectrum Disorder Child Child, Preschool Drug Utilization Female Humans Male Pregnancy Prenatal Exposure Delayed Effects
• Keywords:
  ASD Developmental Disorder Opioid Risk Factor
• Source:
  J Autism Dev Disord. 49(1):376-382
• Pubmed ID:
  30132098
• Pubmed Central ID:
  PMC6331251
• Document Type:
  Journal Article
• Funding:
  U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; u10dd00184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000746/DD/NCBDD CDC HHSUnited States/ ; U10 DD000901/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; u10dd00182/DD/NCBDD CDC HHSUnited States/ ; u10dd0181/DD/NCBDD CDC HHSUnited States/ ; T32 HD007489/HD/NICHD NIH HHSUnited States/ ; U54 HD079124/HD/NICHD NIH HHSUnited States/ ; u10dd000498/DD/NCBDD CDC HHSUnited States/ ; u10dd00183/DD/NCBDD CDC HHSUnited States/ ; u54hd090256/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; t32hd007489/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; u10dd00180/DD/NCBDD CDC HHSUnited States/ ; U01 DD001210/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; U01 DD000749/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001214/DD/NCBDD CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U54 HD090256/HD/NICHD NIH HHSUnited States/ ; U01 DD000748/DD/NCBDD CDC HHSUnited States/
• Volume:
  49
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9bbba966b8e3e62106616ae6861946fa82b48642c1c66a17b0e3ee63d38b8eea
• Download URL:
  https://stacks.cdc.gov/view/cdc/62026/cdc_62026_DS1.pdf
• File Type:
  [PDF - 87.58 KB ]