Pregnancy Planning and its Association with Autism Spectrum Disorder: Findings from the Study to Explore Early Development

Details

• Alternative Title:
  Matern Child Health J
• Personal Author:
  Harris, Shericka T. ; Schieve, Laura A. ; Drews-Botsch, Carolyn ; DiGuiseppi, Carolyn ; Tian, Lin H. ; Soke, Gnakub N. ; Bradley, Chyrise B. ; Windham, Gayle C.
• Description:
  Objectives
  
  To examine associations between pregnancy planning and autism spectrum disorder (ASD) in offspring.
  
  Methods
  
  The Study to Explore Early Development (SEED), a multi-site case-control study, enrolled preschool-aged children with ASD, other DDs, and from the general population (POP). Some children with DDs had ASD symptoms but did not meet the ASD case definition. We examined associations between mother’s report of trying to get pregnant (pregnancy planning) and (1) ASD and (2) ASD symptomatology (ASD group, plus DD with ASD symptoms group combined) (each vs. POP group). We computed odds ratios adjusted for demographic, maternal, health, and perinatal health factors (aORs) via logistic regression. Due to differential associations by race-ethnicity, final analyses were stratified by race-ethnicity.
  
  Results
  
  Pregnancy planning was reported by 66.4%, 64.8%, and 76.6% of non-Hispanic White (NHW) mothers in the ASD, ASD symptomatology, and POP groups, respectively. Among NHW mother-child pairs, pregnancy planning was inversely associated with ASD (aOR = 0.71 [95% confidence interval 0.56–0.91]) and ASD symptomatology (aOR = 0.67 [0.54–0.84]). Pregnancy planning was much less common among non-Hispanic Black mothers (28–32% depending on study group) and Hispanic mothers (49–56%) and was not associated with ASD or ASD symptomatology in these two race-ethnicity groups.
  
  Conclusion
  
  Pregnancy planning was inversely associated with ASD and ASD symptomatology in NHW mother-child pairs. The findings were not explained by several adverse maternal or perinatal health factors. The associations observed in NHW mother-child pairs did not extend to other race-ethnicity groups, for whom pregnancy planning was lower overall.
  
  
• Subjects:
  Autism Spectrum Disorder Black Or African American Case-Control Studies Child, Preschool Ethnicity Female Hispanic Or Latino Humans Mothers Pregnancy White

  More +
• Keywords:
  Developmental Disability Pregnancy Intention Pregnancy Planning Race/Ethnicity
• Source:
  Matern Child Health J. 28(5):949-958
• Pubmed ID:
  38198102
• Pubmed Central ID:
  PMC11001519
• Document Type:
  Journal Article
• Funding:
  U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; National Center on Birth Defects and Developmental Disabilities/DD/NCBDD CDC HHSUnited States/ ; U10 DD000901/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/
• Volume:
  28
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6ba6e22819ce7bb51b8cac998b8b7afdd7985f3c68cf754234676900c32d0f1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/154141/cdc_154141_DS1.pdf
• File Type:
  [PDF - 493.44 KB ]