Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Pirisinu, Laura ; Tran, Linh ; Chiappini, Barbara ; Vanni, Ilaria ; Di Bari, Michele A. ; ... More +
Pirisinu, Laura ; Tran, Linh ; Chiappini, Barbara ; Vanni, Ilaria ; Di Bari, Michele A. ; Vaccari, Gabriele ; Vikøren, Turid ; Madslien, Knut Ivar ; Våge, Jørn ; Spraker, Terry ; Mitchell, Gordon ; Balachandran, Aru ; Baron, Thierry ; Casalone, Cristina ; Rolandsen, Christer M. ; Røed, Knut H. ; Agrimi, Umberto ; Nonno, Romolo ; Benestad, Sylvie L. Less -
Description:
Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large scale surveillance program. The cases occurred in 13-14-year-old female moose, and we detected an abnormal form of prion protein (PrP|) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrP|. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrP| type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
Subjects:
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Alces Alces Cervid Chronic Wasting Disease Cwd Moose Nor16Cwd Novel Type Of Chronic Wasting Disease Detected In Moose (Alces Alces), Norway Prions Reindeer Research Transmissible Spongiform Encephalopathy Tse Zoonoses
Source:
Emerg Infect Dis. 24(12):2210-2218
Pubmed ID:
30457526
Pubmed Central ID:
PMC6256397
Document Type:
Journal Article
Place as Subject:
Norway
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a74e03622bf9f8cb17013cf816f496d98cee26f7736411a240fd4a74f7b112af
Download URL:
https://stacks.cdc.gov/view/cdc/61355/cdc_61355_DS1.pdf
File Type:

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