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Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway
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December 2018
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Source: Emerg Infect Dis. 24(12):2210-2218
[PDF-2.31 MB]
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Alternative Title:Emerg Infect Dis
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Description:Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large scale surveillance program. The cases occurred in 13-14-year-old female moose, and we detected an abnormal form of prion protein (PrP|) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrP|. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrP| type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
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Pubmed ID:30457526
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Pubmed Central ID:PMC6256397
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Volume:24
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Issue:12
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