Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pirisinu, Laura ; Tran, Linh ; Chiappini, Barbara ; Vanni, Ilaria ; Di Bari, Michele A. ; Vaccari, Gabriele ; Vikøren, Turid ; Madslien, Knut Ivar ; Våge, Jørn ; Spraker, Terry ; Mitchell, Gordon ; Balachandran, Aru ; Baron, Thierry ; Casalone, Cristina ; Rolandsen, Christer M. ; Røed, Knut H. ; Agrimi, Umberto ; Nonno, Romolo ; Benestad, Sylvie L.
• Description:
  Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large scale surveillance program. The cases occurred in 13-14-year-old female moose, and we detected an abnormal form of prion protein (PrP|) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrP|. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrP| type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
• Subjects:
  Animals Animals, Wild Brain Female Genotype Immunohistochemistry Prions Public Health Surveillance Reindeer Sheep Wasting Disease, Chronic

  More +
• Source:
  Emerg Infect Dis. 24(12):2210-2218
• Pubmed ID:
  30457526
• Pubmed Central ID:
  PMC6256397
• Document Type:
  Journal Article
• Place as Subject:
  Canada ; Europe ; Norway
• Volume:
  24
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a74e03622bf9f8cb17013cf816f496d98cee26f7736411a240fd4a74f7b112af
• Download URL:
  https://stacks.cdc.gov/view/cdc/61355/cdc_61355_DS1.pdf
• File Type:
  [PDF - 2.31 MB ]