Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Cassmann, Eric D.; Moore, S. Jo; Greenlee, Justin J.

doi:10.3201/eid2712.204978

i

Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Supporting Files Public Domain

12 2021
By Cassmann, Eric D. ; Moore, S. Jo ; Greenlee, Justin J.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cassmann, Eric D. ; Moore, S. Jo ; Greenlee, Justin J.
Description:

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
Subjects:

Animals Deer Mice Prion Diseases Prions Sheep Wasting Disease, Chronic
Source:

Emerg Infect Dis. 2021; 27(12):3156-3158
Pubmed ID:

34808075
Pubmed Central ID:

PMC8632196
Document Type:

Journal Article
Volume:

27
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c74560436d2a407471d3c0ac8a2869b030dfa5e205b4cb90570d2a9e7ef07909
Download URL:

https://stacks.cdc.gov/view/cdc/112601/cdc_112601_DS1.pdf
File Type:

[PDF - 1.28 MB ]

File Language:

English

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