Highly Pathogenic Clone of Shiga Toxin–Producing Escherichia coli O157:H7, England and Wales

Byrne, Lisa; Dallman, Timothy J.; Adams, Natalie; Mikhail, Amy F.W.; McCarthy, Noel; Jenkins, Claire

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Highly Pathogenic Clone of Shiga Toxin–Producing Escherichia coli O157:H7, England and Wales

Supporting Files Public Domain

December 2018
By Byrne, Lisa ; Dallman, Timothy J. ; Adams, Natalie ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Byrne, Lisa ; Dallman, Timothy J. ; Adams, Natalie ; Mikhail, Amy F.W. ; McCarthy, Noel ; Jenkins, Claire
Description:

We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24-9.48; p<0.001), compared with infection with other strains within sublineage IIb. Clinical symptoms of cases infected with sublineage IIb stx2c and stx-negative clones were comparable, despite the loss of stx2c. Our analysis highlighted the highly dynamic nature of STEC O157:H7 Stx-encoding bacteriophages and revealed the evolutionary history of a highly pathogenic clone emerging within sublineage IIb, a sublineage not previously associated with severe clinical symptoms.
Subjects:

Bacteria Enteric Infections Evolution Highly Pathogenic Clone Of Shiga Toxin–producing Escherichia Coli O157:H7, England And Wales Research Shiga Toxin–producing Escherichia Coli STEC Virulence Whole-genome Sequencing
Source:

Emerg Infect Dis. 24(12):2303-2308
Pubmed ID:

30457532
Pubmed Central ID:

PMC6256402
Document Type:

Journal Article
Place as Subject:

England ; Wales ; United Kingdom
Location:

Europe
Volume:

24
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:16c802ee78b6eea7407a4f55cfcd7416e5e54464cd9a67c4702fd2a9a2ed764b
Download URL:

https://stacks.cdc.gov/view/cdc/61347/cdc_61347_DS1.pdf
File Type:

[PDF - 808.12 KB ]

File Language:

English

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