Evolutionary Context of Non–Sorbitol-Fermenting Shiga Toxin–Producing Escherichia coli O55:H7

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Schutz, Kyle ; Cowley, Lauren A. ; Shaaban, Sharif ; Carroll, Anne ; McNamara, Eleanor ; Gally, David L. ; Godbole, Gauri ; Jenkins, Claire ; Dallman, Timothy J.
• Description:
  In July 2014, an outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 in England involved 31 patients, 13 (42%) of whom had hemolytic uremic syndrome. Isolates were sequenced, and the sequences were compared with publicly available sequences of E. coli O55:H7 and O157:H7. A core-genome phylogeny of the evolutionary history of the STEC O55:H7 outbreak strain revealed that the most parsimonious model was a progenitor enteropathogenic O55:H7 sorbitol-fermenting strain, lysogenized by a Shiga toxin (Stx) 2a-encoding phage, followed by loss of the ability to ferment sorbitol because of a non-sense mutation in srlA. The parallel, convergent evolutionary histories of STEC O157:H7 and STEC O55:H7 may indicate a common driver in the evolutionary process. Because emergence of STEC O157:H7 as a clinically significant pathogen was associated with acquisition of the Stx2a-encoding phage, the emergence of STEC O55:H7 harboring the stx2a gene is of public health concern.
• Subjects:
  Bacteria England Evolution Evolutionary Context Of Non–Sorbitol-Fermenting Shiga Toxin–Producing Escherichia Coli O55:H7 Ireland Outbreak Research Shiga Toxin–producing Escherichia Coli Serotype STEC O55:H7 Virulence Whole-genome Sequencing Zoonoses

  More +
• Source:
  Emerg Infect Dis. 23(12):1966-1973.
• Pubmed ID:
  29148397
• Pubmed Central ID:
  PMC5708253
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f1fc1124e6cab354e046ae0541c71639b6eb622c547761338c18d9a46b19925e
• Download URL:
  https://stacks.cdc.gov/view/cdc/50190/cdc_50190_DS1.pdf
• File Type:
  [PDF - 2.02 MB ]