Details:

Alternative Title:
AIDS
Personal Author:
Aldersley, Jordan ; Lorenz, David R. ; Misra, Vikas ; Uno, Hajime ; Gabuzda, Dana ;
Aldersley, Jordan ; Lorenz, David R. ; Misra, Vikas ; Uno, Hajime ; Gabuzda, Dana ; Less -
Description:
Objective(s): HIV-positive individuals have elevated rates of anal squamous cell carcinoma (SCC), and sexually transmitted infections with its causative agent, high-risk human papillomavirus, and other oncoviruses including hepatitis B virus (HBV). HBV infection can cause liver cancer, and has been associated with increased risk of some extra-hepatic cancers including biliary tract cancer, pancreatic cancer, and non-Hodgkin lymphoma. Whether HBV is associated with anal SCC risk is unknown. Design: Prospective study of anal SCC risk in HIV-positive and -negative men who have sex with men (MSM) in the Multicenter AIDS Cohort Study from 1984–2014. Methods: Poisson regression models were used to examine the association between past or current HBV infection (positive tests for HBV core antibodies, surface antigen, and/or DNA) and anal SCC risk. Results: We observed 53 cases of anal SCC among 5,298 participants with 79,334 person-years follow-up. Among HIV-positive men, past or current HBV infection was associated with anal SCC risk in models adjusted for age, CD4+ cell counts, HAART use, and other risk factors (incidence rate ratio [IRR], 95% confidence interval [CI] 3.15, 1.27–7.82). Additional risk factors included immunological parameters one and six years prior to diagnosis (IRR, 95% CI 2.45, 1.31–4.58 and 2.44, 1.3–4.59 for CD4+ counts <500 cells/μl; 2.43, 1.34–4.42 and 2.77, 1.5–5.11 for CD4:CD8 ratios <0.5, respectively). Among HIV-negative men, IRR for prior HBV and anal SCC risk was similar, but not significant due to small number of cases. Conclusions: HIV-positive MSM with prior HBV infection have increased anal SCC risk. This population may benefit from screening.
Subject:
[+]
Anal Cancer
Article
Cancer Epidemiology
Cohort Studies
Hepatitis B Virus
HIV
MSM

Source:
AIDS. 33(1):145-152
Pubmed ID:
30325778
Pubmed Central ID:
PMC6279494
Document Type:
Journal Article ;
Funding:
R01 DA046203/DA/NIDA NIH HHS/United States ; U01 AI035042/AI/NIAID NIH HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; T32 AI007386/AI/NIAID NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; ... More +
R01 DA046203/DA/NIDA NIH HHS/United States ; U01 AI035042/AI/NIAID NIH HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; T32 AI007386/AI/NIAID NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; U01 AI035041/AI/NIAID NIH HHS/United States ; UM1 AI035043/AI/NIAID NIH HHS/United States ; U58 DP000795/DP/NCCDPHP CDC HHS/United States ; R01 DA030985/DA/NIDA NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; UL1 TR000424/TR/NCATS NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U01 AI035043/AI/NIAID NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States ; U01 AI035040/AI/NIAID NIH HHS/United States ; U01 AI035039/AI/NIAID NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7cd591d7ed6945e57590f944e5e013c5d5a8a1f53f293cc4fca6ef0abee5a0de
File Type:

Supporting Files

• 	nihms-1512748.nxml	xml
  	NIHMS1512748-supplement-Supplemental_Digital_Content_1.pdf	pdf
  	NIHMS1512748-supplement-Supplemental_Digital_Content_2.pdf	pdf
  	NIHMS1512748-supplement-Supplemental_Digital_Content_3.pdf	pdf
  	NIHMS1512748-supplement-Supplemental_Digital_Content_4.pdf	pdf

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