Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Chan, Martin C.W. ; Wang, Maggie H. ; Chen, Zigui ; Hui, David S.C. ; Kwok, Angela K. ; ... More +
Chan, Martin C.W. ; Wang, Maggie H. ; Chen, Zigui ; Hui, David S.C. ; Kwok, Angela K. ; Yeung, Apple C.M. ; Liu, Kun M. ; Yeoh, Yun Kit ; Lee, Nelson ; Chan, Paul K.S. ; Less -
Description:
The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.
Subject:
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Hemagglutinin Glycoproteins, Influenza Virus
History, 20th Century
History, 21st Century
Humans
Influenza, Human/epidemiology
Influenza, Human/history
Influenza, Human/prevention & Control
Influenza, Human/virology
Influenza Vaccines
Influenzavirus A
Influenzavirus B
Molecular Epidemiology
Phylogeny
Research
Retrospective Studies
RNA, Viral
Seasons

Source:
Emerg Infect Dis. 24(10):1825-1834.
Pubmed ID:
30226188
Pubmed Central ID:
PMC6154132
Document Type:
Journal Article ;
Place as Subject:
Hong Kong ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d49db4ee8d7f8d908d6d3b3e110afaa699091aaa8dd0d9b728554ba6f7f64dad
File Type:

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