Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chan, Martin C.W. ; Wang, Maggie H. ; Chen, Zigui ; Hui, David S.C. ; Kwok, Angela K. ; Yeung, Apple C.M. ; Liu, Kun M. ; Yeoh, Yun Kit ; Lee, Nelson ; Chan, Paul K.S.
• Description:
  The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.
• Subjects:
  Hemagglutinin Glycoproteins, Influenza Virus History, 20Th Century History, 21St Century Humans Influenza, Human/Epidemiology Influenza, Human/History Influenza, Human/Prevention & Control Influenza, Human/Virology Influenza Vaccines Influenzavirus A Influenzavirus B Molecular Epidemiology Phylogeny Research Retrospective Studies Rna, Viral Seasons

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• Source:
  Emerg Infect Dis. 24(10):1825-1834.
• Pubmed ID:
  30226188
• Pubmed Central ID:
  PMC6154132
• Document Type:
  Journal Article
• Place as Subject:
  Hong Kong
• Volume:
  24
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d49db4ee8d7f8d908d6d3b3e110afaa699091aaa8dd0d9b728554ba6f7f64dad
• Download URL:
  https://stacks.cdc.gov/view/cdc/59473/cdc_59473_DS1.pdf
• File Type:
  [PDF - 2.91 MB ]