Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Imai, Hirotaka ; Dinis, Jorge M. ; Zhong, Gongxun ; Moncla, Louise H. ; Lopes, Tiago J.S. ; ... More +
Imai, Hirotaka ; Dinis, Jorge M. ; Zhong, Gongxun ; Moncla, Louise H. ; Lopes, Tiago J.S. ; McBride, Ryan ; Thompson, Andrew J. ; Peng, Wenjie ; Le, Mai thi Q. ; Hanson, Anthony ; Lauck, Michael ; Sakai-Tagawa, Yuko ; Yamada, Shinya ; Eggenberger, Julie ; O’Connor, David H. ; Suzuki, Yasuo ; Hatta, Masato ; Paulson, James C. ; Neumann, Gabriele ; Friedrich, Thomas C. ; Kawaoka, Yoshihiro Less -
Description:
Influenza viruses exist in each host as a collection of genetically diverse variants, which might enhance their adaptive potential. To assess the genetic and functional diversity of highly pathogenic avian influenza A(H5N1) viruses within infected humans, we used deep-sequencing methods to characterize samples obtained from infected patients in northern Vietnam during 2004-2010 on different days after infection, from different anatomic sites, or both. We detected changes in virus genes that affected receptor binding, polymerase activity, or interferon antagonism, suggesting that these factors could play roles in influenza virus adaptation to humans. However, the frequency of most of these mutations remained low in the samples tested, implying that they were not efficiently selected within these hosts. Our data suggest that adaptation of influenza A(H5N1) viruses is probably stepwise and depends on accumulating combinations of mutations that alter function while maintaining fitness.
Subjects:
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Animals Cell Line Genes, Viral Genetic Variation Hemagglutinin Glycoproteins, Influenza Virus / Genetics History, 21St Century Humans Influenza, Human/Epidemiology Influenza, Human/History Influenza, Human/Virology Influenza A Virus, H5N1 Subtype Molecular Typing Phylogeny Population Surveillance Viral Tropism
Source:
Emerg Infect Dis. 24(7):1128-1238.
Pubmed ID:
29912683
Pubmed Central ID:
PMC6038741
Document Type:
Journal Article
Funding:
R01 AI069274/AI/NIAID NIH HHS/United States ; R01 AI114730/AI/NIAID NIH HHS/United States ; R01 AI125392/AI/NIAID NIH HHS/United States
R01 AI069274/AI/NIAID NIH HHS/United States ; R01 AI114730/AI/NIAID NIH HHS/United States ; R01 AI125392/AI/NIAID NIH HHS/United States Less -
Genre:
Historical Article
Place as Subject:
Vietnam
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:cd2ac70e42d371b7dce66634af90862024250557465a3504cb9f3958b99d66ec
Download URL:
https://stacks.cdc.gov/view/cdc/56930/cdc_56930_DS1.pdf
File Type:

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