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Mortality in Youth-Onset Type 1 and Type 2 Diabetes: the SEARCH for Diabetes in Youth Study
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April 04 2018
Source: J Diabetes Complications. 32(6):545-549 -
Alternative Title:J Diabetes Complications
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Personal Author:
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Description:Aims
To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study.
Methods
We included 8358 individuals newly-diagnosed with type 1 (n=6840) or type 2 (n= 1518) diabetes from 1/1/2002–12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) as observed divided by expected numbers of deaths based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study.
Results
Mean age at diabetes diagnosis was 10.7 years. During 44,893 person-years (PY) of observation (median follow-up=5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15–19 year olds 2.7 (1.7–4.0), and non-Hispanic blacks 2.1 (1.2, 3.4).
Conclusions
Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes. Studies of longer-term mortality in individuals with youth-onset diabetes are warranted.
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Pubmed ID:29685480
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Pubmed Central ID:PMC6089078
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