Mortality in Youth-Onset Type 1 and Type 2 Diabetes: the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Diabetes Complications
• Personal Author:
  Reynolds, Kristi ; Saydah, Sharon H. ; Isom, Scott ; Divers, Jasmin ; Lawrence, Jean M. ; Dabelea, Dana ; Mayer-Davis, Elizabeth J. ; Imperatore, Giuseppina ; Bell, Ronny A. ; Hamman, Richard F.
• Description:
  Aims
  
  To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study.
  
  Methods
  
  We included 8358 individuals newly-diagnosed with type 1 (n=6840) or type 2 (n= 1518) diabetes from 1/1/2002–12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) as observed divided by expected numbers of deaths based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study.
  
  Results
  
  Mean age at diabetes diagnosis was 10.7 years. During 44,893 person-years (PY) of observation (median follow-up=5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15–19 year olds 2.7 (1.7–4.0), and non-Hispanic blacks 2.1 (1.2, 3.4).
  
  Conclusions
  
  Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes. Studies of longer-term mortality in individuals with youth-onset diabetes are warranted.
  
  
• Subjects:
  Article Epidemiology Mortality Type 1 Diabetes Type 2 Diabetes Youth
• Source:
  J Diabetes Complications. 32(6):545-549
• Pubmed ID:
  29685480
• Pubmed Central ID:
  PMC6089078
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHS/United States ; U18DP006139/ACL HHS/ACL HHS/United States ; UC4 DK108173/DK/NIDDK NIH HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U18 DP003256/DP/NCCDPHP CDC HHS/United States ; U18 DP006131/DP/NCCDPHP CDC HHS/United States ; U18 DP002710/DP/NCCDPHP CDC HHS/United States ; U18 DP006134/DP/NCCDPHP CDC HHS/United States ; U18 DP006138/DP/NCCDPHP CDC HHS/United States ; U18DP006138/ACL HHS/ACL HHS/United States ; UL1 TR000154/TR/NCATS NIH HHS/United States ; U18 DP002714/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U18DP006134/ACL HHS/ACL HHS/United States ; U18 DP006136/DP/NCCDPHP CDC HHS/United States ; U18 DP002709/DP/NCCDPHP CDC HHS/United States ; U18 DP006133/DP/NCCDPHP CDC HHS/United States ; U18DP006131/ACL HHS/ACL HHS/United States ; UL1 TR001425/TR/NCATS NIH HHS/United States ; UL1 TR002319/TR/NCATS NIH HHS/United States ; U18 DP006139/DP/NCCDPHP CDC HHS/United States ; UL1 TR000423/TR/NCATS NIH HHS/United States ; U18DP006136/ACL HHS/ACL HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; UL1 TR001450/TR/NCATS NIH HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP006133/ACL HHS/ACL HHS/United States ; U18 DP002708/DP/NCCDPHP CDC HHS/United States
• Volume:
  32
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eacf8a294b7d340bcbbe468c7ee7a97ca2947d0f926e381f123b0d53f890b528
• Download URL:
  https://stacks.cdc.gov/view/cdc/58100/cdc_58100_DS1.pdf
• File Type:
  [PDF - 190.73 KB ]