Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nolfi-Donegan, Deirdre ; Konar, Monica ; Vianzon, Vianca ; MacNeil, Jessica ; Cooper, James ; Lurie, Perrianne ; Sedivy, Judi ; Wang, Xin ; Granoff, Dan M. ; McNamara, Lucy
• Description:
  Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.
• Subjects:
  Adolescent Antibodies, Bacterial Antibodies, Monoclonal, Humanized Dispatch Fatal Outcome Female Hemoglobinuria, Paroxysmal Humans Immunoglobulin G Meningitis, Meningococcal Meningococcal Vaccines Neisseria Meningitidis

  More +
• Source:
  Emerg Infect Dis. 24(8):1561-1564
• Pubmed ID:
  30015608
• Pubmed Central ID:
  PMC6056112
• Document Type:
  Journal Article
• Funding:
  C06 RR016226/RR/NCRR NIH HHS/United States ; R01 AI046464/AI/NIAID NIH HHS/United States ; R01 AI114701/AI/NIAID NIH HHS/United States
• Volume:
  24
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:487addf80b316978c6bd4be5284378882cbb8e5cd91bd33c468d2e1b9bcdbb67
• Download URL:
  https://stacks.cdc.gov/view/cdc/57972/cdc_57972_DS1.pdf
• File Type:
  [PDF - 582.50 KB ]