Details:

Alternative Title:
J Acquir Immune Defic Syndr
Publisher's site:
http://dx.doi.org/10.1097/QAI.0000000000001143
Personal Author:
Gust, Deborah A. ; Soud, Fatma ; Hardnett, Felicia ; Malotte, C. Kevin ; Rose, Charles ; ... More +
Gust, Deborah A. ; Soud, Fatma ; Hardnett, Felicia ; Malotte, C. Kevin ; Rose, Charles ; Kebaabetswe, Poloko ; Makgekgenene, Lebogang ; Henderson, Faith ; Paxton, Lynn ; Segolodi, Tebogo ; Kilmarx, Peter H. Less -
Description:
Objective

Among participants of a clinical trial to test the efficacy of tenofovir/emtricitabine in protecting heterosexual men and women living in Botswana from HIV infection, determine 1) if sexual risk behavior, specifically condomless sex acts and number of sex partners, changed over time, 2) factors associated with condomless sex acts and number of sex partners and 3) the effect of participant treatment arm perception on risk behavior to address the possibility of risk compensation.

Methods

A longitudinal modeling of rates of risk behaviors was used to determine if the rate of condomless sex acts (#acts/person) and rate of sex partners (#partners/person) changed over time and which factors were associated with behavior change.

Results

1200 participants were analyzed over 1 year. There was a 25% decrease in the rate of sex partners among participants sexually active in the last 30 days. The rate of reported condomless sex acts was greater for males (RR=1.34, CI=1.07–1.67) and participants whose sexual debut in years was ≤ 15 years of age (RR=1.65, CI=1.14–2.38) and 16–17 (RR=1.68, CI=1.22–2.31) compared to ≥20 years. Rate of reported sex partners was greater for males (RR=3.67, CI=2.86–4.71) and participants whose age at sexual debut in years was ≤15 (RR=2.92, CI=2.01–4.22) and 16–17 (RR=2.34, CI=1.69–3.24) compared to ≥20. There was no effect of participant treatment arm perception on risk behavior.

Conclusions

Our study of PrEP to prevent HIV infection found no evidence of risk compensation which may have been due to participants’ motivations to reduce their risk behaviors and risk-reduction counseling.


Subject:
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Adult Article Clinical Trial Double-Blind Method Female Healthy Volunteers Heterosexuality HIV Infections Humans Male Models, Statistical Pre-Exposure Prophylaxis Risk-Taking Risk Compensation Sexual Behavior Sexual Risk Behavior Tenofovir/emtricitabine
Source:
J Acquir Immune Defic Syndr. 73(5):556-563.
Pubmed ID:
27509251
Pubmed Central ID:
PMC6066668
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Botswana
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b4a9212af5a3463161b4432ed44da7fade4c9e80ba19bfefc5dd81e62705ad18
Download URL:
https://stacks.cdc.gov/view/cdc/57784/cdc_57784_DS1.pdf
File Type:

Supporting Files

• 	NIHMS805605-supplement-Supplemental_tables.docx	docx
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  	nihms805605f1a.gif	gif
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