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Evaluation of sexual risk behavior among study participants in the TDF2 PrEP study among heterosexual adults in Botswana
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Dec 15 2016
Source: J Acquir Immune Defic Syndr. 73(5):556-563. -
Alternative Title:J Acquir Immune Defic Syndr
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Description:Objective
Among participants of a clinical trial to test the efficacy of tenofovir/emtricitabine in protecting heterosexual men and women living in Botswana from HIV infection, determine 1) if sexual risk behavior, specifically condomless sex acts and number of sex partners, changed over time, 2) factors associated with condomless sex acts and number of sex partners and 3) the effect of participant treatment arm perception on risk behavior to address the possibility of risk compensation.
Methods
A longitudinal modeling of rates of risk behaviors was used to determine if the rate of condomless sex acts (#acts/person) and rate of sex partners (#partners/person) changed over time and which factors were associated with behavior change.
Results
1200 participants were analyzed over 1 year. There was a 25% decrease in the rate of sex partners among participants sexually active in the last 30 days. The rate of reported condomless sex acts was greater for males (RR=1.34, CI=1.07–1.67) and participants whose sexual debut in years was ≤ 15 years of age (RR=1.65, CI=1.14–2.38) and 16–17 (RR=1.68, CI=1.22–2.31) compared to ≥20 years. Rate of reported sex partners was greater for males (RR=3.67, CI=2.86–4.71) and participants whose age at sexual debut in years was ≤15 (RR=2.92, CI=2.01–4.22) and 16–17 (RR=2.34, CI=1.69–3.24) compared to ≥20. There was no effect of participant treatment arm perception on risk behavior.
Conclusions
Our study of PrEP to prevent HIV infection found no evidence of risk compensation which may have been due to participants’ motivations to reduce their risk behaviors and risk-reduction counseling.
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Pubmed ID:27509251
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Pubmed Central ID:PMC6066668
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