Hepatitis B Virus Testing and Care among Pregnant Women Using Commercial Claims Data, United States, 2011–2014

Details

• Alternative Title:
  Infect Dis Obstet Gynecol
• Personal Author:
  Harris, Aaron M. ; Isenhour, Cheryl ; Schillie, Sarah F. ; Vellozzi, Claudia
• Description:
  Introduction
  
  Pregnant women should receive hepatitis B virus (HBV) testing with hepatitis B surface antigen (HBsAg), but it is unclear whether HBV-infected pregnant women are linked to care.
  
  Methods
  
  We analyzed MarketScan™ commercial insurance claims. We included pregnant women, aged 10–50 years, with 42 weeks of continuous enrollment before (predelivery) and 6 months after (postdelivery) the first delivery claim for each unique pregnancy between 1/1/2011 and 6/30/2014. We identified claims for HBsAg testing by CPT code and described the care continuum among pregnancies with an associated ICD-9 HBV diagnosis code by demographic and clinical characteristics, including HBV-directed care ([HBV DNA or hepatitis B e antigen] and ALT test codes) and antiviral treatment (claims for tenofovir, entecavir, lamivudine, adefovir, or telbivudine) pre- and postdelivery.
  
  Results
  
  There were 870,888 unique pregnancies (819,752 women) included. Before delivery, 714,830 (82%) pregnancies had HBsAg test claims, but this proportion decreased with subsequent pregnancies (p < 0.0001): second (80%), third (71%), and fourth (61%). We identified 1,190 (0.14%) pregnancies with an associated HBV diagnosis code: most were among women aged ≥ 30 years (76%) residing in the Pacific (34%) or Middle Atlantic (18%) regions. Forty-two percent of pregnancies with an HBV diagnosis received HBV-directed care (42% predelivery and 39% postdelivery). Antiviral treatment was initiated before delivery in 128 (13%) of 975 pregnancies and postdelivery in 16 (1.6%) pregnancies.
  
  Conclusions
  
  While most of these commercially insured pregnant women received predelivery HBV screening, we identified gaps in HBV testing and the HBV care continuum which highlight potential targets for public health interventions.
  
  
• Subjects:
  Adult Antiviral Agents Databases, Factual Female Hepatitis B Hepatitis B Surface Antigens Hepatitis B Virus Humans Infectious Disease Transmission, Vertical Insurance Claim Review Logistic Models Mass Screening Pregnancy Pregnancy Complications, Infectious Young Adult

  More +
• Source:
  Infect Dis Obstet Gynecol. 2018; 2018.
• Pubmed ID:
  29805248
• Pubmed Central ID:
  PMC5899853
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  2018
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a9b12fd05bd5fd3f988f21c89e6a147dead7ad0d1dec02cf0283011d911bca82
• Download URL:
  https://stacks.cdc.gov/view/cdc/56527/cdc_56527_DS1.pdf
• File Type:
  [PDF - 707.39 KB ]