Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Hentzien, Maxime ; Mestrallet, Stéphanie ; Halin, Pascale ; Pannet, Laure-Anne ; Lebrun, Delphine ; ... More +
Hentzien, Maxime ; Mestrallet, Stéphanie ; Halin, Pascale ; Pannet, Laure-Anne ; Lebrun, Delphine ; Dramé, Moustapha ; Bani-Sadr, Firouzé ; Galempoix, Jean-Marc ; Strady, Christophe ; Reynes, Jean-Marc ; Penalba, Christian ; Servettaz, Amélie Less -
Description:
We conducted a multicenter, retrospective cohort study of hospitalized patients with serologically proven nephropathia epidemica (NE) living in Ardennes Department, France, during 2000-2014 to develop a bioclinical test predictive of severe disease. Among 205 patients, 45 (22.0%) had severe NE. We found the following factors predictive of severe NE: nephrotoxic drug exposure (p = 0.005, point value 10); visual disorders (p = 0.02, point value 8); microscopic or macroscopic hematuria (p = 0.04, point value 7); leukocyte count >10 × 10| cells/L (p = 0.01, point value 9); and thrombocytopenia <90 × 10|/L (p = 0.003, point value 11). When point values for each factor were summed, we found a score of <10 identified low-risk patients (3.3% had severe disease), and a score >20 identified high-risk patients (45.3% had severe disease). If validated in future studies, this test could be used to stratify patients by severity in research studies and in clinical practice.
Subjects:
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Adult Biomarkers Comorbidity Diagnostic Tests, Routine Female Hemorrhagic Fever With Renal Syndrome Hospitalization Humans Male Middle Aged Odds Ratio Prognosis Retrospective Studies Roc Curve Severity Of Illness Index Symptom Assessment Young Adult
Source:
Emerg Infect Dis. 24(6):1045-1054.
Pubmed ID:
29774835
Pubmed Central ID:
PMC6004848
Document Type:
Journal Article
Place as Subject:
France ; Europe
France ; Europe Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:a5183df5d660198a0a0ccf203e7259d3a36b4b3b58a1734eaa389ee56d049e86
Download URL:
https://stacks.cdc.gov/view/cdc/56336/cdc_56336_DS1.pdf
File Type:

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