Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Tappe, Dennis; Schlottau, Kore; Cadar, Daniel; Hoffmann, Bernd; Balke, Lorenz; ... More +
Tappe, Dennis; Schlottau, Kore; Cadar, Daniel; Hoffmann, Bernd; Balke, Lorenz; Bewig, Burkhard; Hoffmann, Donata; Eisermann, Philip; Fickenscher, Helmut; Krumbholz, Andi; Laufs, Helmut; Huhndorf, Monika; Rosenthal, Maria; Schulz-Schaeffer, Walter; Ismer, Gabriele; Hotop, Sven-Kevin; Brönstrup, Mark; Ott, Anthonina; Schmidt-Chanasit, Jonas; Beer, Martin; Less -
Description:
Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost's squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany. Molecular assays and immunohistochemistry detected a limbic distribution of the virus in brain tissue of the animal caretaker. Phylogenetic analyses demonstrated a spillover infection from the Prevost's squirrel. Antibodies against bornaviruses were detected in the patient's cerebrospinal fluid by immunofluorescence and newly developed ELISAs and immunoblot. The putative antigenic epitope was identified on the viral nucleoprotein. Other zoo workers were not infected; however, avoidance of direct contact with exotic squirrels and screening of squirrels are recommended.
Subject:
[+]
Animals
Bornaviridae
Epitope Mapping
Female
History, 21st Century
Humans
Immunohistochemistry
Limbic Encephalitis/diagnosis
Limbic Encephalitis/epidemiology
Limbic Encephalitis/etiology
Limbic Encephalitis/history
Magnetic Resonance Imaging
Middle Aged
Mononegavirales Infections
Occupational Exposure
Phylogeny
RNA, Viral
Sciuridae / Virology
Serologic Tests
Structure-Activity Relationship
Viral Proteins
Whole Genome Sequencing
Zoonoses

Source:
Emerg Infect Dis. 24(6):978-987.;
Pubmed ID:
29774846
Pubmed Central ID:
PMC6004865
Document Type:
Journal Article;
Genre:
Historical Article;
Place as Subject:
Germany;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a48035f475513e8c8f2722f646e6e0c7e6318e801903779b50dfec9725e78fa8
File Type:

Supporting Files

• 	17-2027-Techapp-s1.pdf	pdf
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