Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Vuong, Ann M. ; Braun, Joseph M. ; Webster, Glenys M. ; Zoeller, R. Thomas ; Hoofnagle, Andrew N. ; Sjödin, Andreas ; Yolton, Kimberly ; Lanphear, Bruce P. ; Chen, Aimin
• Description:
  Background
  
  Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood.
  
  Methods
  
  We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003–2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1–3 years. Thyroid hormones were measured in serum at 3 years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3 years.
  
  Results
  
  Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3 years. A 10-fold increase in prenatal ΣPBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI −40.8%, −11.3%) in TSH. A ten-fold increase in prenatal ΣPBDEs was associated with a 0.25 pg/mL (0.07, 0.43) increase in free triiodothyronine (FT3). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T4 (FT4) in males. Prenatal ΣPBDEs were not associated with TT4, FT4, or total T3.
  
  Conclusions
  
  These findings suggest an inverse relationship between prenatal ΣPBDEs and TSH at 3 years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.
  
  
• Subjects:
  Child, Preschool Female Halogenated Diphenyl Ethers Humans Infant Male Maternal Exposure Pregnancy Thyroid Hormones
• Keywords:
  Brominated Flame Retardants Endocrine Disruption Epidemiology Polybrominated Diphenyl Ethers (PBDEs) Thyroid Function Thyroid Hormones
• Source:
  Environ Int. 117:339-347
• Pubmed ID:
  29787984
• Pubmed Central ID:
  PMC5997562
• Document Type:
  Journal Article
• Funding:
  P01 ES011261/ES/NIEHS NIH HHSUnited States/ ; P30 ES006096/ES/NIEHS NIH HHSUnited States/ ; R01 ES014575/ES/NIEHS NIH HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ ; R01 ES028277/ES/NIEHS NIH HHSUnited States/ ; T32 ES010957/ES/NIEHS NIH HHSUnited States/ ; R01 ES020349/ES/NIEHS NIH HHSUnited States/ ; R01 ES024381/ES/NIEHS NIH HHSUnited States/
• Volume:
  117
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:75c94397f3effa9b61a8bf03aad631a399f82a1f1fc31dd0657d1bca86e24e83
• Download URL:
  https://stacks.cdc.gov/view/cdc/55858/cdc_55858_DS1.pdf
• File Type:
  [PDF - 631.36 KB ]