Details:

Alternative Title:
Food Chem
Personal Author:
Sanford, Aimee A. ; Isenberg, Samantha L. ; Carter, Melissa D. ; Mojica, Mike A. ; Mathews, Thomas P. ; ... More +
Sanford, Aimee A. ; Isenberg, Samantha L. ; Carter, Melissa D. ; Mojica, Mike A. ; Mathews, Thomas P. ; Harden, Leslie A. ; Takeoka, Gary R. ; Thomas, Jerry D. ; Pirkle, James L. ; Johnson, Rudolph C. Less -
Description:
Methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in various soapberry (Sapindaceae) fruits. These toxins have been linked to illnesses worldwide and were recently implicated in Asian outbreaks of acute hypoglycemic encephalopathy. In a previous joint agricultural and public health investigation, we developed an analytical method capable of evaluating MCPG and HGA concentrations in soapberry fruit arils as well as a clinical method for the urinary metabolites of the toxins. Since the initial soapberry method only analyzed the aril portion of the fruit, we present here the extension of the method to include the fruit seed matrix. This work is the first method to quantitate both MCPG and HGA concentrations in the seeds of soapberry fruit, including those collected during a public health investigation. Further, this is the first quantitation of HGA in litchi seeds as well as both toxins in mamoncillo and longan seeds.
Subject:
[+]
Article
Chromatography, High Pressure Liquid
Cyclopropanes
Fruit
Glycine
Hypoglycemic Encephalopathy
Hypoglycin A (HGA)
Hypoglycins
Methylenecyclopropylglycine (MCPG)
Sapindaceae
Sapindus
Seeds
Soapberry Seeds
Tandem Mass Spectrometry

Source:
Food Chem. 264:449-454
Pubmed ID:
29853400
Pubmed Central ID:
PMC5985522
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:444a506bdd2a674d0a7d550752b943373fc07f35b1fe3cccf6660f603894d345
File Type:

Supporting Files

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