Quantitative HPLC-MS/MS Analysis of Toxins in Soapberry Seeds: Methylenecyclopropylglycine and Hypoglycin A

Sanford, Aimee A.; Isenberg, Samantha L.; Carter, Melissa D.; Mojica, Mike A.; Mathews, Thomas P.; Harden, Leslie A.; Takeoka, Gary R.; Thomas, Jerry D.; Pirkle, James L.; Johnson, Rudolph C.

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Quantitative HPLC-MS/MS Analysis of Toxins in Soapberry Seeds: Methylenecyclopropylglycine and Hypoglycin A

Published Date:

May 04 2018

Source:

Food Chem. 264:449-454

Language:

English

[PDF-475.04 KB]

Details:

Alternative Title:

Food Chem

Personal Author:

Sanford, Aimee A. ; Isenberg, Samantha L. ; Carter, Melissa D. ; Mojica, Mike A. ; Mathews, Thomas P. ; ... More ▼

Description:

Methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in various soapberry (Sapindaceae) fruits. These toxins have been linked to illnesses worldwide and were recently implicated in Asian outbreaks of acute hypoglycemic encephalopathy. In a previous joint agricultural and public health investigation, we developed an analytical method capable of evaluating MCPG and HGA concentrations in soapberry fruit arils as well as a clinical method for the urinary metabolites of the toxins. Since the initial soapberry method only analyzed the aril portion of the fruit, we present here the extension of the method to include the fruit seed matrix. This work is the first method to quantitate both MCPG and HGA concentrations in the seeds of soapberry fruit, including those collected during a public health investigation. Further, this is the first quantitation of HGA in litchi seeds as well as both toxins in mamoncillo and longan seeds.

Subject:

[+]

Pubmed ID:

29853400

Pubmed Central ID:

PMC5985522

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

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Supporting Files:

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	nihms968689.nxml	text/xml
	nihms968689f1.gif	image/gif
	nihms968689f1.jpg	image/jpeg
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Quantitative HPLC-MS/MS Analysis of Toxins in Soapberry Seeds: Methylenecyclopropylglycine and Hypoglycin A

Quantitative HPLC-MS/MS Analysis of Toxins in Soapberry Seeds: Methylenecyclopropylglycine and Hypoglycin A

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